Combining evolution and self-organization to find natural Boolean representations in unconventional computational media

Egbert, Matthew; Gruenert, Gerd; Ibrahim, Bashar; Dittrich, Peter

doi:10.1016/j.biosystems.2019.104011

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…MTZ desensitization per a validated protocol with the assistance of an allergy specialist is recommended in these situations. (18,(41)(42)(43) While 5nitroimidazoles are the only antimicrobial class known to be effective against T. vaginalis, there is anecdotal evidence for alternative regimens. Given its demonstrated trichomonacidal activity in vitro, (44) intra-vaginal boric acid (BA) 600mg twice daily for 60 days has been used in this clinical setting with some success.…”

Section: Treatment In the Setting Of 5-nitroimidazole Hypersensitivitymentioning

confidence: 99%

Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity

Muzny

Gerwen

Kissinger

2020

Current Opinion in Infectious Diseases

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Purpose of the review: The purpose of this review is to update information on treatment of T. vaginalis. Trichomonas vaginalis is estimated to be the most common treatable sexually transmitted infection (STI) In the world and is associated with poor birth outcomes, cervical cancer, sperm motility and morphology issues, and HIV acquisition and transmission. Recent findings:The efficacy of the recommended 2 gram oral single-dose metronidazole (MTZ) for the treatment of T. vaginalis in women has recently been challenged. Two recent multicentered randomized trials and a meta-analysis have demonstrated that the 7-day dose of MTZ 500 mg twice daily was nearly two times more efficacious at clearing infection compared to the 2 gram dose. Partner treatment is also essential, since up to 70% of male sexual partners can be infected and rescreening of treated women at 3-months is also recommended given the high repeat infection rates. Future studies should examine the importance of treating asymptomatic T. vaginalis, best treatment for men, the influence of the microbiome on treatment efficacy, and different formulations of intra-vaginal treatments for hypersensitivity. Summary: 7 day 500 mg twice daily MTZ should be used as the first line treatment for T. vaginalis infected women.

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Section: Treatment In the Setting Of 5-nitroimidazole Hypersensitivitymentioning

confidence: 99%

Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity

Muzny

Gerwen

Kissinger

2020

Current Opinion in Infectious Diseases

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“…Chemical substrates have been successfully used to implement computations [1][2][3][4][5][6][7][8][9], thus, rendering chemical computers a significant category of unconventional computers. Although some of the examples of these unconventional computers refer to emulating basic and conventional computing procedures [10,11] (i.e., Boolean gates), recently, there has been a drive towards more interesting approaches and higher-complexity computations, like for example pattern recognition [12,13]. One of the best-established non-equilibrium systems utilized for computations is the Belousov-Zhabotinsky (BZ) reaction [14][15][16][17][18][19][20], that is mainly used as a thin layer placed on appropriate architectures (i.e., channels and reservoirs purposely designed).…”

Section: Introductionmentioning

confidence: 99%

Chemical Wave Computing from Labware to Electrical Systems

et al. 2022

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Unconventional and, specifically, wave computing has been repeatedly studied in laboratory based experiments by utilizing chemical systems like a thin film of Belousov–Zhabotinsky (BZ) reactions. Nonetheless, the principles demonstrated by this chemical computer were mimicked by mathematical models to enhance the understanding of these systems and enable a more detailed investigation of their capacity. As expected, the computerized counterparts of the laboratory based experiments are faster and less expensive. A further step of acceleration in wave-based computing is the development of electrical circuits that imitate the dynamics of chemical computers. A key component of the electrical circuits is the memristor which facilitates the non-linear behavior of the chemical systems. As part of this concept, the road-map of the inspiration from wave-based computing on chemical media towards the implementation of equivalent systems on oscillating memristive circuits was studied here. For illustration reasons, the most straightforward example was demonstrated, namely the approximation of Boolean gates.

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Overview of the Methods for Self-Organization in Swarm Robotics

Marinchev¹

2020

TUS

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Self-organization is a common phenomenon observed in many natural and artificial systems. The overall coordinated behavior of the system is due to simple rules for interaction between its components. Thanks to these properties, self-organization plays a key role in swarm robotics, as it allows swarm coordination with minimal complexity of individual robots. This paper reviews the methods and tools for self-organization that are used in swarm robotics or are found in natural systems.

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Combining evolution and self-organization to find natural Boolean representations in unconventional computational media

Cited by 3 publications

References 37 publications

Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity

Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity

Chemical Wave Computing from Labware to Electrical Systems

Overview of the Methods for Self-Organization in Swarm Robotics

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