Combining Evolutionary Inference and Metabolomics to Identify Plants With Medicinal Potential

Mawalagedera, Sundara Mudiyanselage Udayanga; Callahan, Damien L.; Gaskett, Anne C.; Rønsted, Nina; Symonds, Matthew R. E.

doi:10.3389/fevo.2019.00267

Cited by 39 publications

(18 citation statements)

References 89 publications

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“…Fifty percent of the well-known magnoliid families were studied and 62 species were reported to have antibacterial activity ( Figure 4 ). Magnoliids are early angiosperms, comprising four orders, 18 families, and approximately 10,000 species that face relatively high pressure from herbivory ( Turcotte et al, 2014 ; Mawalagedera et al, 2019 ); thus this group is characterized by unique aromatic compounds such as sesquiterpenes, isoflavonoids, and benzylisoquinoline alkaloids (e.g., aporphines, aristolochic acids, and bis-benzylisoquinolines) ( Aminimoghadamfarouj et al, 2011 ; Courtois et al, 2016 ). This suggests that other members in the magnoliids clade, including Piperales, Magnoliales and Laurales could be good candidates for chemical studies.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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Background: Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s’ golden age of discovery. Plants produce a variety of bioactive secondary metabolites that could be used to fuel the future discovery pipeline. While many studies have focused on specific aspects of plants and plant natural products with antibacterial properties, a comprehensive review of the antibacterial potential of plants has never before been attempted.Objectives: This systematic review aims to evaluate reports on plants with significant antibacterial activities.Methods: Following the PRISMA model, we searched three electronic databases: Web of Science, PubMed and SciFinder by using specific keywords: “plant,” “antibacterial,” “inhibitory concentration.”Results: We identified a total of 6,083 articles published between 1946 and 2019 and then reviewed 66% of these (4,024) focusing on articles published between 2012 and 2019. A rigorous selection process was implemented using clear inclusion and exclusion criteria, yielding data on 958 plant species derived from 483 scientific articles. Antibacterial activity is found in 51 of 79 vascular plant orders throughout the phylogenetic tree. Most are reported within eudicots, with the bulk of species being asterids. Antibacterial activity is not prominent in monocotyledons. Phylogenetic distribution strongly supports the concept of chemical evolution across plant clades, especially in more derived eudicot families. The Lamiaceae, Fabaceae and Asteraceae were the most represented plant families, while Cinnamomum verum, Rosmarinus vulgaris and Thymus vulgaris were the most studied species. South Africa was the most represented site of plant collection. Crude extraction in methanol was the most represented type of extraction and leaves were the main plant tissue investigated. Finally, Staphylococcus aureus was the most targeted pathogenic bacteria in these studies. We closely examine 70 prominent medicinal plant species from the 15 families most studied in the literature.Conclusion: This review depicts the current state of knowledge regarding antibacterials from plants and provides powerful recommendations for future research directions.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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“…Plants synthesize secondary metabolites (small organic molecules) that are not required for their normal growth or development but are essentially required for reproduction and defence mechanism against bacteria, fungus, virus, vertebrates, etc. These products have a great potential to act as drugs [43,44]. Many secondary metabolites are involved in the antagonistic relationship between plants and other organisms, but also in mutualistic ones (i.e., plants/pollinators, plants/disseminators, nitrogen-fixing plants/microorganisms, etc.)…”

Section: Plant Secondary Metabolites: Key Target Playermentioning

confidence: 99%

A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery

et al. 2019

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The war on multidrug resistance (MDR) has resulted in the greatest loss to the world’s economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a central role in treating infectious diseases. However, the inappropriate, irregular, and irrational uses of antibiotics have resulted in the emergence of antimicrobial resistance. This has resulted in an increased interest in medicinal plants since 30–50% of current pharmaceuticals and nutraceuticals are plant-derived. The question we address in this review is whether plants, which produce a rich diversity of secondary metabolites, may provide novel antibiotics to tackle MDR microbes and novel chemosensitizers to reclaim currently used antibiotics that have been rendered ineffective by the MDR microbes. Plants synthesize secondary metabolites and phytochemicals and have great potential to act as therapeutics. The main focus of this mini-review is to highlight the potential benefits of plant derived multiple compounds and the importance of phytochemicals for the development of biocompatible therapeutics. In addition, this review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits.

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“…Plants extracts, coupled with hackneyed antibiotics, are found to escalate the antimicrobial activity (Dudhatra et al, 2012;Tatiraju et al, 2013). These metabolites are not required by plants for proper functioning and development, but protection from harmful pathogens like bacteria and virus and help in reproduction (Boy et al, 2018;Mawalagedera et al, 2019). Thus, screening of plants for their antioxidant and antimicrobial activities is the primary and pivotal step to achieve pharmaceutical breakthroughs (Nenaah and Ahmed, 2011).…”

Section: Discussionmentioning

confidence: 99%

Ilex khasiana - The silent holly species of Aquifoliaceae on its pharmacognostical importance as a free radical scavenger and antibacterial agent

Lalnunfela

Lalremsanga

Lalhriatpuii

et al. 2020

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Ilex khasiana is a rare and endangered medicinal plant endemic to northeast India. Remaining largely unexplored,it is purported to have a range of medicinal values and may soon join the medicinal plant hall of fame.Extracts of the leaves were prepared using solvents of increasing polarity, namelypetroleum ether (IKP), chloroform (IKC) and methanol (IKM).The preliminary phytochemical screening indicated the presence of alkaloids, phytosterols, triterpenoids, saponins, reducing sugars, glycosides and carbohydrates. Free radical-scavenging activity was assessed using2,2-diphenyl-1-picrylhydrazyl(DPPH). IKC exhibited the highest activity with an IC50 of 17.22 ± 1.87, followed by IKM with an IC50 of 26.93 ± 5.14 and IKP with an IC50 of 37.16 ± 5.11. Butylated hydroxytoluene (BHT)was used as the standard DPPH scavenger and showed an IC50 of 8.31 ±0.72. IKM and IKC also showed positive antibacterial activity againstGram-negative bacteria such asEscherichia coli, Pseudomonas aeruginosa, andKlebsiella pneumoniae, and a Gram-positive bacteriaBacillus subtilis. IKP did not indicate any inhibition against the selected bacteria. Our findings substantiate the basis for further investigations on the medicinal potentials of the plant.

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Combining Evolutionary Inference and Metabolomics to Identify Plants With Medicinal Potential

Cited by 39 publications

References 89 publications

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery

Ilex khasiana - The silent holly species of Aquifoliaceae on its pharmacognostical importance as a free radical scavenger and antibacterial agent

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