Combining fMRI and MEG increases the reliability of presurgical language localization: A clinical study on the difference between and congruence of both modalities

Grummich, P.; Nimsky, Christopher; Pauli, E.; Buchfelder, Michael; Ganslandt, Oliver

doi:10.1016/j.neuroimage.2006.05.034

Cited by 83 publications

(48 citation statements)

References 41 publications

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“…The spatial relationship between brain areas identified as exhibiting a task induced signal change by BOLD fMRI and MEG is of significant interest, particularly in applications such as presurgical planning (Grummich et al, 2006) where spatial precision is paramount. However, the question of whether BOLD and neuromagnetic signals originate from the same brain location is, to an extent, confounded by the limits of spatial resolution, and the differences between MEG and fMRI.…”

Section: Spatial Relationshipsmentioning

confidence: 99%

The relationship between MEG and fMRI

et al. 2014

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In recent years functional neuroimaging techniques such as fMRI, MEG, EEG and PET have provided researchers with a wealth of information on human brain function. However none of these modalities can measure directly either the neuro-electrical or neuro-chemical processes that mediate brain function. This means that metrics directly reflecting brain 'activity' must be inferred from other metrics (e.g. magnetic fields (MEG) or haemodynamics (fMRI)). To overcome this limitation, many studies seek to combine multiple complementary modalities and an excellent example of this is the combination of MEG (which has high temporal resolution) with fMRI (which has high spatial resolution). However, the full potential of multi-modal approaches can only be truly realised in cases where the relationship between metrics is known. In this paper, we explore the relationship between measurements made using fMRI and MEG. We describe the origins of the two signals as well as their relationship to electrophysiology. We review multiple studies that have attempted to characterise the spatial relationship between fMRI and MEG, and we also describe studies that exploit the rich information content of MEG to explore differing relationships between MEG and fMRI across neural oscillatory frequency bands. Monitoring the brain at "rest" has become of significant recent interest to the neuroimaging community and we review recent evidence comparing MEG and fMRI metrics of functional connectivity. A brief discussion of the use of magnetic resonance spectroscopy (MRS) to probe the relationship between MEG/fMRI and neurochemistry is also given. Finally, we highlight future areas of interest and offer some recommendations for the parallel use of fMRI and MEG.

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Section: Spatial Relationshipsmentioning

confidence: 99%

The relationship between MEG and fMRI

et al. 2014

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“…As previously stated, concordance with the IAP is high for TLE, but may drop to 75% or lower in patients with extratemporal epilepsy. Finally, there is evidence that the hemodynamic response in fMRI is suppressed in a sizable number of patients with lesions that result in abnormal vascularization (82,83), making fMRI unreliable in many patients with large gliomas or AVMs. Nevertheless, fMRI provides a cost-efficient, noninvasive method of language and memory localization, and its wide availability makes it a strong contender for eventually replacing the IAP.…”

Section: Fmrimentioning

confidence: 99%

“…Third, MEG is not distorted by tissues outside the brain that affect EEG, which may allow for greater spatial resolution and accuracy (85). Finally, MEG may be a powerful tool for identifying receptive language fields that are impacted by dominant temporal lobe resections (68,82).…”

Section: Megmentioning

confidence: 99%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

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“…Various modalities, such as the Wada test, fMRI, functional PET, and magnetoencephalography, can be used for non-invasive localization or lateralization of language area(s) for presurgical purposes. The Wada test and fMRI are the most popular of these modalities 5,6,12,24) . Although the Wada test can serve as a useful index of language laterality, it is less useful for localizing language areas.…”

Section: Overviewmentioning

confidence: 99%

“…Functional magnetic resonance imaging (fMRI) has been frequently used to localize language areas in the brain in a non-invasive manner [1][2][3][4][5][6][7][8]12,13,15,16,18,19,[24][25][26] . Various paradigms for the presurgical localization of language areas have been developed to replace invasive brain mapping.…”

Section: Introductionmentioning

confidence: 99%

Localization of Broca's Area Using Functional MR Imaging: Quantitative Evaluation of Paradigms

Kim

Chung

et al. 2009

J Korean Neurosurg Soc

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Objective : Functional magnetic resonance imaging (fMRI) is frequently used to localize language areas in a non-invasive manner. Various paradigms for presurgical localization of language areas have been developed, but a systematic quantitative evaluation of the efficiency of those paradigms has not been performed. In the present study, the authors analyzed different language paradigms to see which paradigm is most efficient in localizing frontal language areas. Methods : Five men and five women with no neurological deficits participated (mean age, 24 years) in this study. All volunteers were righthanded. Each subject performed 4 tasks, including fixation (Fix), sentence reading (SR), pseudoword reading (PR), and word generation (WG). Fixation and pseudoword reading were used as contrasts. The functional area was defined as the area(s) with a t-value of more than 3.92 in fMRI with different tasks. To apply an anatomical constraint, we used a brain atlas mapping system, which is available in AFNI, to define the anatomical frontal language area. The numbers of voxels in overlapped area between anatomical and functional area were individually counted in the frontal expressive language area. Results : Of the various combinations, the word generation task was most effective in delineating the frontal expressive language area when fixation was used as a contrast (p<0.05). The sensitivity of this test for localizing Broca's area was 81% and specificity was 70%. Conclusion : Word generation versus fixation could effectively and reliably delineate the frontal language area. A customized effective paradigm should be analyzed in order to evaluate various language functions.

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Combining fMRI and MEG increases the reliability of presurgical language localization: A clinical study on the difference between and congruence of both modalities

Cited by 83 publications

References 41 publications

The relationship between MEG and fMRI

The relationship between MEG and fMRI

The use of neuroimaging to study behavior in patients with epilepsy

Localization of Broca's Area Using Functional MR Imaging: Quantitative Evaluation of Paradigms

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