Combining functional imaging with brain stimulation in Parkinson's disease

Obeso, Ignacio; Ray, Nicola; Antonelli, Francesca; Cho, Sang Soo; Strafella, Antonio P.

doi:10.3109/09540261.2011.621414

Cited by 6 publications

(3 citation statements)

References 105 publications

(125 reference statements)

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“…However, because of the complex role and interactions of the basal ganglia, techniques that are able to globally assess brain function and activity, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), must also be implemented to elucidate the effects of DBS. 26 fMRI in particular is able to evaluate global brain activation with high temporal and spatial resolution.…”

Section: Introductionmentioning

confidence: 99%

Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease

Knight

Testini

Min

et al. 2015

Mayo Clinic Proceedings

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Objective To test the hypothesis suggested by previous studies that subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with PD would affect the activity of both motor and non-motor networks, we applied intraoperative fMRI to patients receiving DBS. Patients and Methods Ten patients receiving STN DBS for PD underwent intraoperative 1.5T fMRI during high frequency stimulation delivered via an external pulse generator. The study was conducted between the dates of January 1, 2013 and September 30, 2014. Results We observed blood oxygen level dependent (BOLD) signal changes (FDR<.001) in the motor circuitry, including primary motor, premotor, and supplementary motor cortices, thalamus, pedunculopontine nucleus (PPN), and cerebellum, as well as in the limbic circuitry, including cingulate and insular cortices. Activation of the motor network was observed also after applying a Bonferroni correction (p<.001) to our dataset, suggesting that, across subjects, BOLD changes in the motor circuitry are more consistent compared to those occurring in the non-motor network. Conclusions These findings support the modulatory role of STN DBS on the activity of motor and non-motor networks, and suggest complex mechanisms at the basis of the efficacy of this treatment modality. Furthermore, these results suggest that, across subjects, BOLD changes in the motor circuitry are more consistent compared to those occurring in the non-motor network. With further studies combining the use of real time intraoperative fMRI with clinical outcomes in patients treated with DBS, functional imaging techniques have the potential not only to elucidate the mechanisms of DBS functioning, but also to guide and assist in the surgical treatment of patients affected by movement and neuropsychiatric disorders.

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Section: Introductionmentioning

confidence: 99%

Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease

Knight

Testini

Min

et al. 2015

Mayo Clinic Proceedings

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“…Recently, there has been a trend toward combining TMS and rTMS with other techniques as BOLD-fMRI ( 75 ). In some interesting work, treatment with either fluoxetine or rTMS was given to depressed PD patients ( 76 ).…”

Section: Resultsmentioning

confidence: 99%

Magnetic Resonance Techniques Applied to the Diagnosis and Treatment of Parkinson’s Disease

et al. 2015

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Parkinson’s disease (PD) affects at least 10 million people worldwide. It is a neurodegenerative disease, which is currently diagnosed by neurological examination. No neuroimaging investigation or blood biomarker is available to aid diagnosis and prognosis. Most effort toward diagnosis using magnetic resonance (MR) has been focused on the use of structural/anatomical neuroimaging and diffusion tensor imaging (DTI). However, deep brain stimulation, a current strategy for treating PD, is guided by MR imaging (MRI). For clinical prognosis, diagnosis, and follow-up investigations, blood oxygen level-dependent MRI, DTI, spectroscopy, and transcranial magnetic stimulation have been used. These techniques represent the state of the art in the last 5 years. Here, we focus on MR techniques for the diagnosis and treatment of Parkinson’s disease.

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“…Thus, individualized 906 parameter settings based on neurophysiologic oscillation studies 907 may be further developed as a way to better control symptoms in 908 PD patients. Different neuroimaging methods (PET and fMRI) have been 911 used to examine the physiological changes in neuronal networks 912 produced by DBS (Obeso et al, 2011;Ko and Strafella, 2012). [ 123 I]iodobenzamide SPECT for dopamine system).…”

Section: Dbs Acting Through Modulation Of Oscillationsmentioning

confidence: 99%

The mechanisms of action of deep brain stimulation and ideas for the future development

Udupa

Chen

2015

Progress in Neurobiology

129

133

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Combining functional imaging with brain stimulation in Parkinson's disease

Cited by 6 publications

References 105 publications

Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease

Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease

Magnetic Resonance Techniques Applied to the Diagnosis and Treatment of Parkinson’s Disease

The mechanisms of action of deep brain stimulation and ideas for the future development

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