Combining gellan gum with a functional low-molecular-weight gelator to assemble stiff shaped hybrid hydrogels for stem cell growth

Piras, Carmen C.; Genever, Paul; Smith, David K.

doi:10.1039/d2ma00565d

Cited by 11 publications

(12 citation statements)

References 95 publications

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“…To stiffen the system, shell growth was also performed in the presence of 0.4 wt %/vol gellan gum (GG). This polymer gelator (PG) becomes incorporated into the growing DBS-COOH shell, and visibly stiffens it, making the core–shell objects more robust . Acid can also induce GG assemblywe propose both DBS-CO 2 H and GG networks are activated in this way (see evidence below).…”

Section: Resultsmentioning

confidence: 99%

Fabricating Shaped and Patterned Supramolecular Multigelator Objects via Diffusion-Adhesion Gel Assembly

Tangsombun,

Smith

2023

J. Am. Chem. Soc.

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We report the use of acid-diffusion to assemble core–shell supramolecular gel beads with different low-molecular-weight gelators (LMWGs) in the core and shell. These gel beads grow a shell of dibenzylidenesorbitol-based DBS-COOH onto a core comprising DBS-CONHNH2 and agarose that has been loaded with acetic acid. Diffusion of the acid from the core triggers shell assembly. The presence of DBS-CONHNH2 enables the gel core to be loaded with metal nanoparticles (NPs) as acyl hydrazide reduces metal salts in situ. The pH-responsiveness of DBS-COOH allows responsive assembly of the shell with both temporal and spatial control. By fixing multiple gel beads in a Petri dish, the cores become linked to one another by the assembled DBS-COOH gel shella process we describe as diffusion-adhesion assembly. By controlling the geometry of the beads with respect to one another, it is possible to pattern the structures, and using a layer-by-layer approach, 3D objects can be fabricated. If some of the beads are loaded with basic DBS-carboxylate instead of CH3COOH, they act as a “sink” for diffusing protons, preventing DBS-COOH shell assembly in the close proximity. Those beads do not adhere to the remainder of the growing gel object and can be simply removed once diffusion-assembly is complete, acting as templates, and enabling the fabrication of 3D “imprinted” multigel architectures. Preloading the gel beads with AuNPs or AgNPs suspends these functional units within the cores at precisely defined locations within a wider gel object. In summary, this approach enables the dynamic fabrication of shaped and patterned gels with embedded metal NPssuch objects have potential next-generation applications in areas including soft nanoelectronics and regenerative medicine.

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Section: Resultsmentioning

confidence: 99%

Fabricating Shaped and Patterned Supramolecular Multigelator Objects via Diffusion-Adhesion Gel Assembly

Tangsombun,

Smith

2023

J. Am. Chem. Soc.

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“…We have also developed methods to fabricate hybrid gel beads with other polymers like agarose and gellan gum. 269…”

Section: Emergence Of Supramolecular Conceptsmentioning

confidence: 99%

Supramolecular gels – a panorama of low-molecular-weight gelators from ancient origins to next-generation technologies

Smith

2024

Soft Matter

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“…There were various preparation strategies to fabricate supramolecular-polymeric composite hydrogels mainly by the preformation of polymeric networks or the postpolymerization of monomers. 6,10,17,54,55 Supramolecular-polymeric composite hydrogels have also been widely applied in many fields, such as biosensors, 27 electrolytes, 41 delivery vehicles, 56 cell culture scaffolds, 57 bioinspired lubricants, 58 biocatalysts, 59 and antioxidant wound dressings. 15 However, the incorporation of polymeric networks into composite hydrogels by using supramolecular networks as mimic enzymatic polymerization systems and the preparation of multifunctional supramolecular-polymeric hydrogel wound dressings with antioxidant, antibacterial and conductive properties for accelerating wound repair have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Mimic enzymatic preparation of conductive supramolecular-polymeric hydrogels with antibacterial and antioxidant properties for accelerating wound healing

et al. 2023

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Combining gellan gum with a functional low-molecular-weight gelator to assemble stiff shaped hybrid hydrogels for stem cell growth

Abstract: Hybrid hydrogels combining gellan gum polymer gelator (PG) with a low molecular weight gelator (LMWG) benefit from both the synergistic combination of rheological characteristics and the unique activity of the LMWG.

Cited by 11 publications

References 95 publications

Fabricating Shaped and Patterned Supramolecular Multigelator Objects via Diffusion-Adhesion Gel Assembly

Fabricating Shaped and Patterned Supramolecular Multigelator Objects via Diffusion-Adhesion Gel Assembly

Supramolecular gels – a panorama of low-molecular-weight gelators from ancient origins to next-generation technologies

Mimic enzymatic preparation of conductive supramolecular-polymeric hydrogels with antibacterial and antioxidant properties for accelerating wound healing

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