2022
DOI: 10.3390/vaccines11010016
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Combining Influenza and COVID-19 Booster Vaccination Strategy to Improve Vaccination Uptake Necessary for Managing the Health Pandemic: A Systematic Review and Meta-Analysis

Abstract: Background: The uptake of COVID-19 booster vaccines has been significantly low. Therefore, it is questionable whether combining the COVID-19 booster vaccines with influenza vaccines can increase the population’s interest in taking such vaccines and manage the health pandemic effectively. Methodology: In this systematic review and meta-analysis, a synthesis of the findings and summary of a total of 30 research articles based on the topic, ‘combining influenza and COVID-19 booster vaccination strategy’ was under… Show more

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Cited by 11 publications
(9 citation statements)
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“…All t-tests of items were significant at the 0.001 degree. Specifically, χ 2 (453) = 4037.916; Chi-square/df = 8.914; p < 0.01; GFI = 0.902 > 0.9; AGFI = 0.879 > 0.8; CFI = 0.950 > 0.9; TLI = 0.942 > 0.9; NFI = 0.945 > 0.9 and RMSEA = 0.054 < 0.08 [ 1 , 32 , 44 ] (Anderson and Gerbing, 1988). In addition, the CFA results also revealed that the standardized regression weights of all observed variables were higher than 0.5 [ 9 , 32 , 33 , 45 ].…”
Section: Resultsmentioning
confidence: 99%
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“…All t-tests of items were significant at the 0.001 degree. Specifically, χ 2 (453) = 4037.916; Chi-square/df = 8.914; p < 0.01; GFI = 0.902 > 0.9; AGFI = 0.879 > 0.8; CFI = 0.950 > 0.9; TLI = 0.942 > 0.9; NFI = 0.945 > 0.9 and RMSEA = 0.054 < 0.08 [ 1 , 32 , 44 ] (Anderson and Gerbing, 1988). In addition, the CFA results also revealed that the standardized regression weights of all observed variables were higher than 0.5 [ 9 , 32 , 33 , 45 ].…”
Section: Resultsmentioning
confidence: 99%
“…Third, this study only focused on some antecedents of intentions to receive COVID-19 vaccines, including perceived clinical and access barriers, self-efficacy, and attitudes towards COVID-19 vaccines, further studies can extend the conceptual framework to explore other factors which affect individuals’ intention to receive COVID-19 vaccines. Last, some scales used in our study, which developed by some prior studies, such as Mir et al [ 13 , 32 ], Chu and Liu [ 11 ], and Coe et al [ 26 ]. Although their validity and reliability have been reported through Cronbach’s alpha and CFA, further studies can adopt other scales which can reflect the constructs of perceived clinical and access barriers, self-efficacy, attitudes towards COVID-19 vaccines, psychological distress, and intentions to receive COVID-19 vaccines better.…”
Section: Discussionmentioning
confidence: 99%
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“…A number of studies, straddling different countries, age-groups, and combinations of different influenza vaccines and COVID-19 boosters have now reported on findings with respect to co-administering the two vaccines compared to giving one or the other first. 1 , 2 , 3 , 4 , 5 The endpoints have comprised adverse event profiles and immunogenicity, although with no data as yet on efficacy. A new addition to this important dataset comes with publication of the TACTIC study – over-60s given Pfizer mRNA booster first and quadrivalent influenza vaccine 3-weeks later, quadrivalent influenza vaccine with Pfizer booster 3-weeks later, both simultaneously or Pfizer mRNA booster alone.…”
mentioning
confidence: 99%
“…The breadth of studies now encompass: flu vaccination in the form of trivalent or tetravalent as well as adjuvanted MF59C, and COVID-19 vaccines, either at 2nd or 3rd dose, of Pfizer, Moderna, AstraZeneca or Novavax. 1 , 2 , 3 , 4 , 5 The trend across these studies is that influenza antibody responses tend to be unaltered by simultaneous administration, while the IgG response to SARS-CoV-2 spike is generally unaltered or non-significantly reduced – that is, geometric mean ratios between concomitant and separate administration was always greater than 0.67, the cut-off used by WHO in defining vaccine non-inferiority. The TACTIC study, however, finds less potent cross-neutralizing antibody responses against variants of concern and failed to show non-inferiority for antibody binding against ancestral spike.…”
mentioning
confidence: 99%