Combining ion chromatography with mass spectrometry and inductively coupled plasma‐mass spectrometry: Annual review 2020

Abstract

The demand for analyzing low molecular weight polar and ionic components in body fluids, pharmaceutical formulations, food, environmental samples, and drinking water is increasing. Ion chromatography (IC) offers significant advantages over RPLC and HILIC due to a complementary chromatographic selectivity, a different retention mechanism, and a high tolerance toward complex matrices. A continuously regenerated membrane desalter simplifies the combination of IC‐applications with MS‐ or MS/MS‐detection, improving the sensitivity and specificity. Analytical workflows are streamlined, providing higher sample throughput. Combining IC with ICP‐MS simplifies the speciation analysis of inorganic and organic polar components. The knowledge about the distribution of an element among chemical species in a sample is essential due to significantly different toxicological or environmental properties. This annual review evaluates the literature published from late 2019 until November 2020.

Ultra-trace determination of oxyhalides in ozonated aquacultural marine waters by direct injection ion chromatography coupled with triple-quadrupole mass spectrometry

“…Modern quantitative MS (e.g., triple quadrupole-based mass analysers) is now also routinely available, which provides high sensitivity and selectivity across the low mass range for small ions, delivering detection limits in the low ppt (ng L-1) range for target inorganic species. There have been several reviews on the combination of IC-MS published over recent years, where these advantages and the various applications of the coupled technique are discussed in greater detail [17,18,19].…”