Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury

Vasconcelos, Natália L.; Gomes, Eduardo D.; Oliveira, Eduarda P.; Silva, Carlos J.; Lima, Rui; Sousa, Nuno; Salgado, António J.; Silva, Nuno

doi:10.1016/j.spinee.2016.04.013

Cited by 28 publications

(41 citation statements)

References 201 publications

(223 reference statements)

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“…; Vasconcelos et al . ). The two studies using mm 2 data showed that, with riluzole treatment, there was tissue preservation up to 1.5 mm from the damage epicenter (Simard et al .…”

Section: Resultsmentioning

confidence: 97%

“…; Vasconcelos et al . ), and the remaining studies used an aneurysm clip compression method (Schwartz and Fehlings ; Satkunendrarajah and Fehlings ; Wu et al . ; Can et al .…”

Section: Resultsmentioning

confidence: 99%

“…; Vasconcelos et al . ), while one study did not report volumetric data in the vehicle group (Simard et al . ).…”

Section: Resultsmentioning

confidence: 99%

“…; Vasconcelos et al . ), or all studies. A moderate or high heterogeneity was still observed using all exclusion methods.…”

Section: Resultsmentioning

confidence: 99%

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Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta‐analysis and systematic review

Zhou

Tian

Yao

et al. 2019

Journal of Neurochemistry

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Spinal cord injury (SCI) is a devastating condition that has few treatment options. Riluzole, a sodium channel blocker used to treat amyotrophic lateral sclerosis, has been initially trialed in human SCI. We performed a systematic review to critically assess the efficacy of riluzole in locomotor recovery and damage extension in SCI rat models, and the potential for clinical translation. PubMed, Embase, Cochrane Library, and Chinese databases were searched from their inception date to March 2018. Two reviewers independently selected animal studies that evaluated neurological recovery and lesion area following riluzole treatment in SCI rat models, extracted data and assessed methodological quality. Pairwise meta‐analysis, subgroup analysis, and network meta‐analysis were performed to assess the effects of riluzole on SCI. Ten eligible studies were included. Two studies had high methodological quality. Overall, the Basso, Beattie, and Bresnahan scores were increased in riluzole‐treated animals versus controls, and effect sizes showed a gradual increase from the 1st (five studies, n = 104, mean difference = 1.24, 95% CI = 0.11 to 2.37, p = 0.03) to 6th week after treatment (five studies, n = 120, mean difference = 2.34, 95% CI = 1.26 to 3.42, p < 0.0001). Riluzole was associated with improved outcomes in the inclined plane test and the tissue preservation area. Subgroup analyses suggested an association of locomotor recovery with riluzole dose. Network meta‐analysis showed that 5 mg/kg riluzole exhibited greater protection than 2.5 and 8 mg/kg riluzole. Collectively, this review suggests that riluzole has a protective effect on SCI, with good safety and a clear mechanism of action and may be suitable for future clinical trials or applications. However, animal results should be interpreted with caution given the known limitations in animal experimental design and methodological quality.

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“…; Vasconcelos et al . ). The two studies using mm 2 data showed that, with riluzole treatment, there was tissue preservation up to 1.5 mm from the damage epicenter (Simard et al .…”

Section: Resultsmentioning

confidence: 97%

“…; Vasconcelos et al . ), and the remaining studies used an aneurysm clip compression method (Schwartz and Fehlings ; Satkunendrarajah and Fehlings ; Wu et al . ; Can et al .…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta‐analysis and systematic review

Zhou

Tian

Yao

et al. 2019

Journal of Neurochemistry

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show abstract

“…Although current therapies, such as novel drugs [1] or neurorehabilitation [2] have been developed to treat Spinal Cord Injury (SCI), these therapies could not achieve radical cure. Cell-based therapy using Mesenchymal Stem Cells (MSCs) has been gaining attention as a novel approach to treat the damage caused by SCI.…”

Section: Introductionmentioning

confidence: 99%

Hypoxic Preconditioning Increases the Neuroprotective Effects of Mesenchymal Stem Cells in a Rat Model of Spinal Cord Injury

Imura¹,

Tomiyasu²,

Otsuru³

et al. 2017

J Stem Cell Res Ther

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Cenobamate: Neuroprotective Potential of a New Antiepileptic Drug

2020

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Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury

Abstract: Our results suggest that the combined treatment, although simultaneously targeting two excitotoxic-related mechanisms, did not further improve behavioral and histologic outcome when compared with riluzole given alone.

Cited by 28 publications

References 201 publications

Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta‐analysis and systematic review

Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta‐analysis and systematic review

Hypoxic Preconditioning Increases the Neuroprotective Effects of Mesenchymal Stem Cells in a Rat Model of Spinal Cord Injury

Cenobamate: Neuroprotective Potential of a New Antiepileptic Drug

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