Combining Proteomic Strategies and Molecular Display Technology for Development of Vaccines against Candida albicans

Karasaki, Seiji Shibasaki Miki

doi:10.4172/jpb.1000313

J Proteomics Bioinform

2014

DOI: 10.4172/jpb.1000313

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Combining Proteomic Strategies and Molecular Display Technology for Development of Vaccines against Candida albicans

Seiji Shibasaki Miki Karasaki¹

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2018

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Molecular and Physiological Study of Candida albicans by Quantitative Proteome Analysis

2018

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Candida albicans is one of the major pathogens that cause the serious infectious condition known as candidiasis. C. albicans was investigated by proteome analysis to systematically examine its virulence factors and to promote the development of novel pharmaceuticals against candidiasis. Here, we review quantitative time-course proteomics data related to C. albicans adaptation to fetal bovine serum, which were obtained using a nano-liquid chromatography/tandem mass spectrometry system equipped with a long monolithic silica capillary column. It was revealed that C. albicans induced proteins involved in iron acquisition, detoxification of oxidative species, energy production, and pleiotropic stress tolerance. Native interactions of C. albicans with macrophages were also investigated with the same proteome-analysis system. Simultaneous analysis of C. albicans and macrophages without isolating individual living cells revealed an attractive strategy for studying the survival of C. albicans. Although those data were obtained by performing proteome analyses, the molecular physiology of C. albicans is discussed and trials related to pharmaceutical applications are also examined.

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Molecular and Physiological Study of Candida albicans by Quantitative Proteome Analysis

2018

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Combining Proteomic Strategies and Molecular Display Technology for Development of Vaccines against Candida albicans

Cited by 1 publication

References 43 publications

Molecular and Physiological Study of Candida albicans by Quantitative Proteome Analysis

Molecular and Physiological Study of Candida albicans by Quantitative Proteome Analysis

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