Background and AimsThe rapid expansion of artificial intelligence (AI) within worldwide healthcare systems is occurring at a significant rate. In this context, the Middle East has demonstrated distinctive characteristics in the application of AI within the healthcare sector, particularly shaped by regional policies. This study examined the outcomes resulting from the utilization of AI within healthcare systems in the Middle East.MethodsA systematic review was conducted across several databases, including PubMed, Scopus, ProQuest, and the Cochrane Database of Systematic Reviews in 2024. The quality assessment of the included studies was conducted using the Authority, Accuracy, Coverage, Objectivity, Date, Significance checklist. Following this, a thematic analysis was carried out on the acquired data, adhering to the Boyatzis approach.Results100 papers were included. The quality and bias risk of the included studies were delineated to be within an acceptable range. Multiple themes were derived from the thematic analysis including: “Prediction of diseases, their diagnosis, and outcomes,” “Prediction of organizational issues and attributes,” “Prediction of mental health issues and attributes,” “Prediction of polypharmacy and emotional analysis of texts,” “Prediction of climate change issues and attributes,” and “Prediction and identification of success and satisfaction among healthcare individuals.”ConclusionThe findings emphasized AI's significant potential in addressing prevalent healthcare challenges in the Middle East, such as cancer, diabetes, and climate change. AI has the potential to overhaul the healthcare systems. The findings also highlighted the need for policymakers and administrators to develop a concrete plan to effectively integrate AI into healthcare systems.