Combining symptoms and biomarkers: The future diagnostic approach for disorders of gut‐brain interaction?

Abstract

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Understanding and managing patients with overlapping disorders of gut–brain interaction

“…Diagnostic categorization of DGBI depends on accurate assessment of the presenting symptom pattern and severity, as revealed by the patient during history taking (2). Indeed, as currently no suitable biomarkers are available, the symptom pattern is the main determinant of individual DGBI diagnosis (18) This requires sufficient time and skill from the clinician and also ability of the patient to understand and express individual symptoms and their distinctions (19). Additionally, diagnostic categorization of DGBI as defined by the Rome consensus is not only driven by the presence of specific symptoms, but also their level of intensity and frequency, which need to exceed specific diagnostic threshold values (2,6,7).…”