Combining Ultrasound Pulse-Echo and Transmission Computed Tomography for Quantitative Imaging the Cortical Shell of Long-Bone Replicas

Shortell, Matthew P.; Althomali, Marwan A.M.; Wille, Marie‐Luise; Langton, Christian

doi:10.3389/fmats.2017.00040

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…2). Conceptually, RTT could be considered a kind of ultrasound computed tomography [50][51][52][53][54] . Unlike tomography, however, RTT compares signals with the head present to reference signals acquired in water (free field), thus specifically determining the relative attenuation of each ultrasonic beam.…”

Section: Discussionmentioning

confidence: 99%

Controlled noninvasive modulation of deep brain regions in humans

Riis,

Feldman,

Mickey

et al. 2024

Commun Eng

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Transcranial focused ultrasound provides noninvasive and reversible approaches for precise and personalized manipulations of brain circuits, with the potential to transform our understanding of brain function and treatments of brain dysfunction. However, effective applications in humans have been limited by the human head, which attenuates and distorts ultrasound severely and unpredictably. This has led to uncertain ultrasound intensities delivered into the brain. Here, we address this lingering barrier using a direct measurement approach that can be repeatedly applied to the human brain. The approach uses an ultrasonic scan of the head to measure and compensate for the attenuation of the ultrasound by all obstacles within the ultrasound path. No other imaging modality is required and the method is parameter-free and personalized to each subject. The approach accurately restores operators’ intended intensities inside ex-vivo human skulls. Moreover, the approach is critical for effective modulation of deep brain regions in humans. When applied, the approach modulates fMRI Blood Oxygen Level Dependent (BOLD) activity in disease-relevant deep brain regions. This tool unlocks the potential of emerging approaches based on low-intensity ultrasound for controlled manipulations of neural circuits in humans.

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Section: Discussionmentioning

confidence: 99%

Controlled noninvasive modulation of deep brain regions in humans

Riis,

Feldman,

Mickey

et al. 2024

Commun Eng

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show abstract

“…2 ). Conceptually, RTT could be considered a kind of ultrasound computed tomography, which has been applied for studying acoustic properties of soft-tissues 55 , bone 56,57 , and skull and brain imaging 58,59 . Unlike tomography, however, RTT specifically aims to correct for object aberrations, performing scans with the object present and absent, and implementing relative computations.…”

Section: Discussionmentioning

confidence: 99%

Controlled delivery of ultrasound through the head for effective and safe therapies of the brain

Riis

Wilson

Kubanek

2022

Preprint

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Transcranial focused ultrasound provides noninvasive and reversible approaches for precise and personalized manipulations of brain circuits, with the potential to transform our understanding of brain function and treatments of brain dysfunction. However, the effectiveness and safety of these approaches have been limited by the human head, which attenuates and distorts ultrasound strongly and unpredictably. To address this lingering barrier, we have developed a Relative Through-Transmit (RTT) approach that directly measures and compensates for the attenuation and distortion of a given skull and scalp. We have implemented RTT in hardware and demonstrated that it accurately restores the operator's intended intensities inside ex-vivo human skulls. Moreover, this functionality enabled effective and intensity-dependent transcranial modulation of nerves and effective release of defined doses of propofol inside the skull. RTT was essential for these new applications of transcranial ultrasound; when not applied, there were no significant differences from sham conditions. Moreover, RTT was safely applied in humans and accounted for all intervening obstacles including hair and ultrasound coupling. This method and hardware unlock the potential of ultrasound-based approaches to provide effective, safe, and reproducible precision therapies of the brain.

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“…The image is morphological and remains qualitative. Quantitative parametric approaches have been proposed by several groups, but the pre-and postprocessing times are increased [20,21]. Recently, Wiskin et al [15,16] proposed a compound (reflection/transmission) high-frequency (3 MHz), high-energy quantitative USCT, and the results on a complete knee organ, including the skin, the muscle and the bone, were very convincing.…”

Section: Introductionmentioning

confidence: 99%

Reflection-Mode Ultrasound Computed Tomography Based on Wavelet Processing for High-Contrast Anatomical and Morphometric Imaging

et al. 2021

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Medical B-mode ultrasound is widely used for the examination of children’s limbs, including soft tissue, muscle, and bone. However, for the accurate examination of the bone only, it is often replaced by more restrictive clinical modalities. Several authors have investigated ultrasonic imaging of bone to assess cortical thickness and/or to estimate the wave velocity through the internal structure. The present work focuses on the transverse slice imaging process using reflection-mode ultrasound computed tomography (USCT). The method is valid for imaging soft tissues with similar acoustic impedances, but in the presence of bone, the higher contrasts alter the propagation of ultrasonic waves and reduce the contrast-to-noise ratio (CNR). There is a need to change the methods used for the processing of ultrasonic signals. Our group has developed a wavelet-based coded excitation (WCE) method to process information in frequency and time. The objective of this study is to use the method to improve reflection-mode USCT, at low ultrasonic intensities, to better address organ morphometry. Experimental results on a newborn arm phantom and on an ex vivo chicken drumstick are presented, and the usefulness of this WCE-mode USCT is discussed.

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Combining Ultrasound Pulse-Echo and Transmission Computed Tomography for Quantitative Imaging the Cortical Shell of Long-Bone Replicas

Cited by 6 publications

References 14 publications

Controlled noninvasive modulation of deep brain regions in humans

Controlled noninvasive modulation of deep brain regions in humans

Controlled delivery of ultrasound through the head for effective and safe therapies of the brain

Reflection-Mode Ultrasound Computed Tomography Based on Wavelet Processing for High-Contrast Anatomical and Morphometric Imaging

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