Combining Untargeted and Targeted Metabolomic Profiling Reveals Principal Differences between Osteopenia, Osteoporosis and Healthy Controls
Bing Tan,
Yan Cheng,
Junfeng Li
et al.
Abstract:Backgound: Osteopenia (ON) and osteoporosis (OP) are highly prevalent among postmenopausal women and poses a challenge for early diagnosis. Therefore, identifying reliable biomarkers for early prediction using metabolomics is critically important. Methods: Initially, non-targeted metabolomics was utilized to identify plasma metabolites in healthy controls (HC), ON, and OP groups, aiming to find differential metabolites among these groups. Subsequently, key metabolites were validated through targeted metabolomi… Show more
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