Combining β‐core fragment and total oestriol measurements to test for Down syndrome pregnancies

Cole, Laurence A.; Acuña, E. M.; Isozaki, Takeo; Palomaki, Glenn E.; Bahado‐Singh, Ray O.; Mahoney, MauriceJ.

doi:10.1002/(sici)1097-0223(199712)17:12<1125::aid-pd201>3.0.co;2-#

Cited by 20 publications

(3 citation statements)

References 23 publications

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“…Regardless of the reason, the ␤-core fragment of hCG has not received wide application. Other urine markers have also been investigated, including hCG, free ␤-hCG, and total estriol (28,30 ), but the results for these analytes were less promising, and they have not been incorporated into screening protocols.…”

Section: Discussionmentioning

confidence: 99%

Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples

Palomaki

Knight

Roberson³

et al. 2004

Clinical Chemistry

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Background: Down syndrome screening is commonly performed in the US using maternal age and three or four second-trimester maternal serum markers that can identify up to 75% of affected pregnancies by offering diagnostic studies to 5% of women. Invasive trophoblast antigen [ITA; hyperglycosylated human chorionic gonadotropin (hCG)] is a promising marker that can be measured in urine or serum in the first or second trimester. We report preliminary results for urinary ITA in an ongoing observational study. Methods: Women undergoing second-trimester amniocentesis for reasons not associated with biochemical testing provided consent and a urine (and possibly serum) sample that was tested within a few days. Demographic and pregnancy-related information was collected, along with karyotype. Screening performance was modeled for ITA alone and in combination with serum markers Results: Twelve recruitment centers collected urine from 2055 women with singleton pregnancies between 15 and 20 weeks of gestation (2023 unaffected, 28 Down syndrome, and 4 pregnancies with other chromosome abnormalities). After correction for gestational age, urine concentration, and maternal race and weight, the ITA measurements were higher in women with a Down

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Section: Discussionmentioning

confidence: 99%

Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples

Palomaki

Knight

Roberson³

et al. 2004

Clinical Chemistry

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show abstract

“…Collection and consent procedures have been described previously (Cole et al, 1997b;Isozaki et al, 1997). All samples were refrigerated upon collection, aliquoted and frozen at 20 C in the laboratory.…”

Section: Methodsmentioning

confidence: 99%

“…All samples were refrigerated upon collection, aliquoted and frozen at 20 C in the laboratory. Personal information, assay results, gestational ages (based on ultrasound) and karyotype were recorded in a computer spreadsheet (Cole et al, 1997b;Isozaki et al, 1997). For this study we tested 152 urine samples.…”

Section: Methodsmentioning

confidence: 99%

Hyperglycosylated hcg, a potential alternative to hcg in Down syndrome screening

et al. 1998

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Urinary free beta hCG, beta core fragment and total oestriol as markers of Down syndrome in the second trimester of pregnancy

Hsu

Spencer

Aitken³

et al. 1999

Prenat. Diagn.

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Combining β‐core fragment and total oestriol measurements to test for Down syndrome pregnancies

Cited by 20 publications

References 23 publications

Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples

Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples

Hyperglycosylated hcg, a potential alternative to hcg in Down syndrome screening

Urinary free beta hCG, beta core fragment and total oestriol as markers of Down syndrome in the second trimester of pregnancy

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