Combretodendron africanum bark extract as an antifertility agent. I: Estrogenic effects in vivo and lh release by cultured gonadotrope cells

Benie, Tanon; Izzi, Asmahan El; Tahiri, C; Duval, Jacques; Thieulant, Marie-Lise

doi:10.1016/0378-8741(90)90093-9

Cited by 30 publications

(16 citation statements)

References 6 publications

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“…These plants were: Afrormosia laxiflora, Benth, Fabaceae, Pterocarpus erinaceus, Poire Encycl., Fabaceae, Cola nitida, Schott and Andl, Sterculiaceae and Combretodendron macrocarpum, Keay, Barringtoniaceae. These plant extracts were also shown to induce oestrogen-like, anti-oestrogen-like activities in rat uterus (Benie et al, 1990;Benie et al, unpublished). The abortive effects of aqueous extracts of C. macrocarpum have been ascertained in mice (Bouquet et al, 1967) and hypotensive activity has been found in methanol extracts (Sandberg and Cronlund, 1982).…”

Section: Introductionmentioning

confidence: 91%

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Interaction of some traditional plant extracts with uterine oestrogen or progestin receptors

Benie

Thieulant

2003

Phytotherapy Research

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Previous work has demonstrated that stem bark extracts of Combretodendron macrocarpum (Barringtoniaceae), Cola nitida (Sterculiaceae), Afrormosia laxiflora and Pterocarpus erinaceus (Fabaceae) blocked the oestrus cycle of female rats through antigonadotropic activity. Moreover, a study of the plant substances responsible for these effects revealed the presence of phyto-anti-oestrogens in these plant extracts. In order to explain the mechanism by which these substances exert their antifertility actions, the interaction of the plant extract with oestrogen and progesterone receptors was studied. All crude extracts exerted inhibition of ((3)H)-oestradiol or ((3)H)-Organon binding to their respective receptors but their relative affinities were much lower than those of oestradiol or progesterone. Respective efficiencies of plant extracts in competing for the oestrogen receptor were as follows: A. laxiflora > P. erinaceus > C. macrocarpum > C. nitida. The efficiency order of competition for the progestin receptor was different to that of oestrogen. The most potent competitor was C. macrocarpum extract, followed by P. erinaceus, C. nitida and A. laxiflora. Moreover, the interaction between oestradiol and plant extracts with the oestrogen receptor was determined to be competitive only for C. macrocarpum and A. laxiflora, whereas all compounds produced a competitive inhibition on the progestin receptor binding. These results suggest that the plant extract binding site was the same site as for the steroid. These results suggest also that crude plant extracts may interfere with natural oestrogen and/or progestagen in vivo by binding to steroid receptors.

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Section: Introductionmentioning

confidence: 91%

“…These sterols could induce both competitive inhibition on uterine steroid receptors and the observed oestrogen-like activity such as water imbibition and uterine growth (Benie et al, 1990). Yet, this activity may be provoked by triterpenic saponins contained in C. macrocarpum extracts which stimulate gonadotropin release in vitro.…”

Section: Inhibition Of [mentioning

confidence: 98%

Interaction of some traditional plant extracts with uterine oestrogen or progestin receptors

Benie

Thieulant

2003

Phytotherapy Research

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“…Saponins have been reported to affect the release of hormones, such as LH from the pituitary (Benie et al, 1990); this hormone is considered to regulate all aspects of teleost reproduction (Suzuki et al, 1988a), particularly final oocyte maturation and ovulation (Suzuki et al, 1988b). Therefore, it was hypothesised that induction of changes in LH secretory pattern by QS or its degraded products absorbed Effects and applications of phytochemicals from the intestine might be responsible for the effects that have been observed on reproduction.…”

Section: Observations)mentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

378

214

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Livestock and aquaculture production is under political and social pressure, especially in the European Union (EU), to decrease pollution and environmental damage arising due to animal agriculture. The EU has banned the use of antibiotics and other chemicals, which have been shown to be effective in promoting growth and reducing environment pollutants because of the risk caused to humans by chemical residues in food and by antibiotic resistance being passed on to human pathogens. As a result of this, scientists have intensified efforts in exploiting plants, plant extracts or natural plant compounds as potential natural alternatives for enhancing the livestock productivity. This paper discusses work on the effects of various phytochemicals and plant secondary metabolites in ruminant and fish species. The focus is on (i) plants such as Ananas comosus (pine apple), Momordica charantia (bitter gourd) and Azadirachta indica (neem) containing anthelmintic compounds and for their use for controlling internal parasites; (ii) plants containing polyphenols and their applications for protecting proteins from degradation in the rumen, increasing efficiency of microbial protein synthesis in rumen and decreasing methane emission; for using as antioxidants, antibacterial and antihelmintic agents; and for changing meat colour and for increasing n-3 fatty acids and conjugated linoleic acid in meat; (iii) saponin-rich plants such as quillaja, yucca and Sapindus saponaria for increasing the efficiency of rumen fermentation, decreasing methane emission and enhancing growth; for producing desired nutritional attributes such as lowering of cholesterol in monogastric animals; for increasing growth of fish (common carp and Nile tilapia) and for changing male to female ratio in tilapia; and for use as molluscicidal agents; (iv) Moringa oleifera leaves as a source of plant growth factor(s), antioxidants, beta-carotene, vitamin C, and various glucosinolates and their degraded products for possible use as antibacterial, antioxidant, anticarcinogenic and antipest agents; (v) Jatropha curcas toxic variety with high levels of various phytochemicals such as trypsin inhibitor, lectin, phytate and phorbol esters in seeds limiting the use of seed meal in fish and livestock diets; and the use of phorbol esters as bio-pesticidal agent; and (vi) lesser-known legumes such as Entada phaseoloides seeds containing high levels of trypsin inhibitor and saponins, Sesbania aculeate seeds rich in non-starch polysaccharides and Mucuna pruriens var. utilis seeds rich in L-3,4-dihydroxyphenylalanine and their potential as fish feed; Cassia fistula seeds as a source of antioxidants; and the use of Canavalia ensiformis, C. gladiata and C. virosa seeds containing high levels of trypsin inhinitor, lectins and canavanine. The paper also presents some challenges and future areas of work in this field.

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“…Indeed, ComAbbreviations: ER, estrogen receptor; PR, progesterone receptor; AR, androgen receptor; FBS, fetal bovine serum; DMEM, Dulbecco's modified Eagle's medium; CS, charcoal-stripped; ERE, estrogen responsive element; ARE, androgen responsive element. bretodendron macrocarpum, Afrormosia laxiflora, Pterocarpus erinaceus and Cola nitida extracts blocked the rat estrous cycle and ovulation by decreasing gonadotropin release and synthesis in pituitary gland (Benie et al, 1990. Daldinia concentrica (Xylariaceae, Daldinia concentrica) and Psathyrella efflorescens (Coprinaceae, Psathyrella efflorescens) are two fungi used as folk remedies in Côte d'Ivoire to treat many diseases.…”

Section: Introductionmentioning

confidence: 99%

Estrogen effects of Daldinia concentrica and Psathyrella efflorescens extracts in vitro

Benie¹,

Kouakou²,

Thieulant

2008

Journal of Ethnopharmacology

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Combretodendron africanum bark extract as an antifertility agent. I: Estrogenic effects in vivo and lh release by cultured gonadotrope cells

Cited by 30 publications

References 6 publications

Interaction of some traditional plant extracts with uterine oestrogen or progestin receptors

Interaction of some traditional plant extracts with uterine oestrogen or progestin receptors

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Estrogen effects of Daldinia concentrica and Psathyrella efflorescens extracts in vitro

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