Comedonal Diffusion of Minocycline in Acne

Chosidow, Olivier; Poli, F.; Naline, Emmanuel; Advenier, C.; Revuz, J.

doi:10.1159/000017852

Cited by 8 publications

(5 citation statements)

References 2 publications

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“…These anti-inflammatory and antioxidant properties, as well as the inhibition of collagenase, are important for the management of skin diseases [29]. When compared to tetracycline and doxycycline in vivo, minocycline is more effective against C. acnes, which may be due to minocycline's high lipophilicity, allowing it to achieve higher sebaceous follicular concentrations compared to other tetracyclines [30].…”

Section: Treatment Of Acne and Rosacea With The Tetracycline Class An...mentioning

confidence: 99%

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

et al. 2021

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Resistance of Cutibacterium acnes to topical antibiotics historically used to treat acne (topical erythromycin and clindamycin and, more recently, topical azithromycin and clarithromycin) has been steadily increasing and new topical antibiotics are needed. Minocycline is a semisynthetic tetracycline-derived antibiotic currently used systemically to treat a wide range of infections caused by Gram-negative and Gram-positive bacteria. In addition to its antibiotic activity, minocycline possesses anti-inflammatory properties, such as the downregulation of proinflammatory cytokine production, suppression of neutrophil chemotaxis, activation of superoxide dismutase, and inhibition of phagocytosis, among others. These characteristics make minocycline a valuable agent for treatment of dermatological diseases such as acne vulgaris and papulopustular rosacea. However, more frequent or serious adverse effects have been observed upon the systemic administration of minocycline than with other tetracyclines. Examples of serious adverse effects include hypersensitivity syndrome reaction, drug-induced lupus, idiopathic intracranial hypertension, and other autoimmune syndromes that may cause death. Here, we review adverse effects and drug–drug interactions observed with oral administration of minocycline and contrast this with topical minocycline formulations recently approved or under development for effectively treating dermatological disorders with fewer adverse effects and less drug interaction.

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Section: Treatment Of Acne and Rosacea With The Tetracycline Class An...mentioning

confidence: 99%

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

et al. 2021

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“…in higher concentrations in the pilosebaceous apparatus after oral administration. 14 The major limitation of minocycline is its rare serious adverse effects.…”

Section: Late-onset Fever Associated With Minocycline Therapy Grim Et Almentioning

confidence: 99%

Late‐Onset Drug Fever Associated with Minocycline: Case Report and Review of the Literature

Grim¹,

Romanelli²,

Jennings³

et al. 2003

Pharmacotherapy

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A 15-year-old Caucasian boy experienced severe fever, fatigue, and a 40-lb weight loss after 2 years of minocycline therapy. A workup for infectious causes was negative. One week after minocycline discontinuation, the patient reported that his fever had resolved. Two months later, he reported full resolution of symptoms, weight gain, and a return to normal activity. An objective causality assessment indicated that his illness probably was caused by minocycline, which is considered a safe drug; however, it has been associated with rare serious adverse effects. This patient's presentation of fever was noteworthy not only because minocycline is a rare cause of drug fever, but also because of the delayed onset. Clinicians should be aware that minocycline may cause severe fever and illness even after an extended period of drug exposure.

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“…The medium contained minocycline at the following concentrations: 1.5, 3 or 6 mg/ml. These concentrations were chosen to match that in serum, which is evaluated between 0.7 and 6.5 mg/ml (9). Medium without minocycline was used as a control.…”

Section: Explant Technique In In£ammatory Skinmentioning

confidence: 99%

Minocycline Modulation of Alpha-MSH Production by Keratinocytes In vitro

Sainte-Marie

Tenaud²,

Jumbou³

et al. 1999

Acta Dermato-Venereologica

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The anti-inflammatory mechanisms of minocycline, an antibiotic used in the treatment of the inflammatory component of acne, are only partially understood. In addition to inflammation due to cytokines (IL-1, IL-6, TNF-alpha, etc.), recent studies have shown that neuropeptide-mediated neurogenic inflammation may play an important role in cutaneous inflammation. The purpose of this study was to investigate minocycline-induced modulation of cutaneous production of alpha-melanocyte-stimulating hormone (alpha-MSH), a neuropeptide with known anti-inflammatory activity. Two different skin models were used: explants of inflammatory skin and reconstituted skin, both incubated with minocycline at different concentrations and for different time periods. Epidermal production of alpha-MSH, as evaluated by immunofluorescence and immunoperoxidase techniques, showed increased expression in both models. This neuropeptide, which has an anti-inflammatory activity (notably through production of IL-10, antagonism of IL-1 and inhibition of the chemotaxis of polymorphonuclear leukocytes), thus plays a role in the anti-inflammatory action of minocycline.

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Comedonal Diffusion of Minocycline in Acne

Cited by 8 publications

References 2 publications

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

Late‐Onset Drug Fever Associated with Minocycline: Case Report and Review of the Literature

Minocycline Modulation of Alpha-MSH Production by Keratinocytes In vitro

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