Comet Assay Evaluation of Lanthanum Nitrate DNA Damage in C57-ras Transgenic Mice

Han, Gaochao; Tan, Zhiping; Jing, Huaiqi; Ning, Junyu; Li, Zinan; Gao, Shan; Li, Guojun

doi:10.1007/s12011-020-02500-5

Cited by 11 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidemiological studies on exposed cohorts have shown that REE exposure can lead to an increase in urinary 8-OHdG, suggesting that DNA oxidative stress damage is a potential mechanism of health hazards caused by REEs [75]. A large number of in vitro and in vivo experiments have confirmed that REE exposure can directly or indirectly activate oxidative stress, induce the cleavage of DNA repair protein Poly ADP-ribose polymerase (PARP), prevent chromosome agglutination, and lead to DNA damage [96][97][98][99]. In addition, cell experiments with internalized REE particles showed an increase in DNA double-strand break marker proteins, γ-H 2 AX, and a decrease in DNA repair proteins such as p-53 and PARP, confirming that REEs can induce genetic changes and cause DNA damage [100,101].…”

Section: Geneticsmentioning

confidence: 99%

Toxic Effects of Rare Earth Elements on Human Health: A Review

Wang,

Yang,

Wang

et al. 2024

Toxics

View full text Add to dashboard Cite

Rare earth elements (REEs) are a new type of material resource which have attracted significant attention in recent years. REEs have emerged as essential metals in modern-day technology due to their unique functions. The long-term, large-scale mining and utilization of rare earths has caused serious environmental pollution and constitutes a global health issue, which has raised concerns regarding the safety of human health. However, the toxicity profile of suspended particulate matter in REEs in the environment, which interacts with the human body, remains largely unknown. Studies have shown that REEs can enter the human body through a variety of pathways, leading to a variety of organ and system dysfunctions through changes in genetics, epigenetics, and signaling pathways. Through an extensive literature search and critical analysis, we provide a comprehensive overview of the available evidence, identify knowledge gaps, and make recommendations for future research directions.

show abstract

Section: Geneticsmentioning

confidence: 99%

Toxic Effects of Rare Earth Elements on Human Health: A Review

Wang,

Yang,

Wang

et al. 2024

Toxics

View full text Add to dashboard Cite

show abstract

“…The applicant provided additional evidence regarding the assessment of genotoxicity of lanthanum compounds in the form of two published papers (Damment et al., 2005 ; Han et al., 2021 ).…”

Section: Assessmentmentioning

confidence: 99%

“…The applicant provided also a recent study by Han et al. ( 2021 ) reporting an in vivo rodent alkaline comet assay performed with lanthanum nitrate in C57‐ras transgenic mice and wild type animals following OECD TG 489 (2016). Mice were treated by oral gavage for 180 days (26 weeks) with 12.5, 25 and 50 mg lanthanum nitrate/kg bw.…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of a feed additive consisting of lanthanum carbonate octahydrate (Lanthan One) for cats (Porus GmbH)

Bampidis¹,

Azimonti²,

Bastos³

et al. 2022

EFS2

View full text Add to dashboard Cite

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of lanthanum carbonate octahydrate (Lanthan One) as a zootechnical feed additive for cats. The FEEDAP Panel concluded that lanthanum carbonate octahydrate is safe for cats at the maximum proposed use level of 7,500 mg/kg complete feed. The additive is not irritant to skin or eyes, is not a skin sensitiser and exposure of users by inhalation is considered unlikely. The Panel also concluded that the additive is efficacious as a phosphate binder in adult cats at the minimum proposed conditions of use (1,500 mg/kg complete feedingstuffs).

show abstract

“…Lanthanum (La) is one of the most common elements of REEs (rare earth elements), and it has been widely utilized in diverse fields for decades, including agriculture, catalysis, pharmacology, and electronics ( 5 , 6 ). Yearly La production in China is 45,000 tons, making it the second-highest element of REEs production in China ( 7 ). Studies have revealed that La enters and accumulates in the body via numerous routes, including skin absorption, respiratory and dietary intake via the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

U-Shaped Relationship of Rare Earth Element Lanthanum and Oral Cancer Risk: A Propensity Score-Based Study in the Southeast of China

Chen

Deng

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

As an important rare earth element (REE) extensively applied to industry, agriculture, and medicine, lanthanum (La) has attracted a host of health concerns. This study aimed to explore the relationship between La exposure and the risk of developing oral cancer through a case-control study with a large sample size. Serum La levels of 430 oral cancer patients and 1,118 healthy controls were detected by inductively coupled plasma mass spectrometry (ICP-MS). The association of La level with the risk of oral cancer was assessed in two ways: (1) as a continuous scale based on restricted cubic splines (RCS); (2) as a priori defined centile categories using multivariate logistic regression model, based on propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). The RCS revealed a non-linear U-shaped relationship between serum La and oral cancer risk. Serum La deficiency or excess was associated with an increased risk of oral cancer. When the La level was analyzed as a categorical variable, a similar U-shaped association was observed. Of note, compared to those with La concentrations of 0.243–0.341 μg/L (reference quantiles, 41st−60th), the risk was increased in those with the lower or higher quantiles (0.132–0.242 μg/L vs. 0.243–0.341 μg/L: OR = 1.80, 95%CI: 1.07–3.02; 0.342–0.497 μg/L vs. 0.243–0.341 μg/L: OR = 2.30, 95%CI: 1.38–3.84). The results were generally consistent with the PSM and IPTW analyses. This preliminary study provides strong evidence that there was a U-shaped relationship between serum La levels and oral cancer risk. Much additional work is warranted to confirm our findings.

show abstract

Comet Assay Evaluation of Lanthanum Nitrate DNA Damage in C57-ras Transgenic Mice

Cited by 11 publications

References 37 publications

Toxic Effects of Rare Earth Elements on Human Health: A Review

Toxic Effects of Rare Earth Elements on Human Health: A Review

Safety and efficacy of a feed additive consisting of lanthanum carbonate octahydrate (Lanthan One) for cats (Porus GmbH)

U-Shaped Relationship of Rare Earth Element Lanthanum and Oral Cancer Risk: A Propensity Score-Based Study in the Southeast of China

Contact Info

Product

Resources

About