Commensal microbiota divergently affect myeloid subsets in the mammalian central nervous system during homeostasis and disease

Sankowski, Roman; Ahmari, Jasmin; Mezö, Charlotte; Angelis, Anna Lena Hrabě de; Fuchs, Vidmante; Utermöhlen, Olaf; Buch, Thorsten; Blank, Thomas; Agüero, Mercedes Gomez de; Erny, Daniel

doi:10.15252/embj.2021108605

Cited by 17 publications

(25 citation statements)

References 62 publications

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“…Meanwhile, PVMs participated in experimental allergic encephalomyelitis (EAE) or hypertension. Polfliet MMJ, 85,104 Galea I, 105 and Faraco G 52 were representative researchers of Vrije Univ Amsterdam whose research directions were perivascular and meningeal macrophages in EAE or hypertension. EAE had the longest emergence time of keywords burst from 1997 to 2007, meaning researchers continued to pay attention to them, which is also consistent with the result of cluster analysis 44,85 …”

Section: Discussionmentioning

confidence: 99%

Trends in perivascular macrophages research from 1997 to 2021: A bibliometric analysis

Xie

Chen

et al. 2022

CNS Neurosci Ther

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Introduction: Perivascular macrophages (PVMs) play pivotal roles in maintaining the physiological function of the brain. Dysfunction of PVMs is emerging as an important mechanism in various disease conditions in the brain. Methods: In this work, we analyzed recent research advances in PVMs, especially in the brain, from the Web of Science (WoS) core database using bibliometric analysis based on the search terms "perivascular macrophages" and "perivascular macrophage" on October 27, 2021. Visualization and collaboration analysis were performed by Citespace (5.8 R3 mac). Results: We found 2384 articles published between 1997 and 2021 in the field of PVMs, which were selected for analysis. PVMs were involved in several physio-pathological fields, in which Neurosciences and Neurology, Neuroscience, Immunology, Pathology, and Cardiovascular System and Cardiology were most reported. The research focuses on PVMs mainly in the central nervous system (CNS), inflammation, macrophage or T-cell, and disease, and highlights the related basic research regarding its activation, oxidative stress, angiotensin II, and insulin resistance. Tumor-associated macrophage, obesity, myeloid cell, and inflammation were relatively recent highlight keywords that attracted increasing attention in recent years.

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Section: Discussionmentioning

confidence: 99%

Trends in perivascular macrophages research from 1997 to 2021: A bibliometric analysis

Xie

Chen

et al. 2022

CNS Neurosci Ther

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“…This notion has encouraged several probiotic treatment approaches. Indeed, application of probiotic bacterial strains alleviated DSS-induced colitis, reduced systemic and CNS cytokine levels, induced micro-RNA expression related to restoring inflammation-associated microbiota dysbiosis, and improved depressive and anxiety-like behavior [ 146 , 147 , 148 , 149 ]. However, it is unclear whether effects of probiotic treatments were solely indirect based on the reduction in gut inflammation or also directly interfered with inflammatory gut-to-brain communication or neurons.…”

Section: Impact Of Microbiota On Neuroinflammation and Neuropsychiatr...mentioning

confidence: 99%

“…First, microbiota and microbiota-derived molecules actively shape the CNS immune landscape, and the presence of a complex microbiota is essential for microglia activation and function [ 148 , 150 , 151 , 152 ]. Among other CNS-associated myeloid cell types, commensal microbiota strongly influence CP macrophages, while their impact on perivascular and meningeal macrophages is moderate [ 148 ]. Different microbial metabolites were described to modulate microglia.…”

Section: Impact Of Microbiota On Neuroinflammation and Neuropsychiatr...mentioning

confidence: 99%

The Gut–Immune–Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease

Masanetz

Winkler

Winner

et al. 2022

IJMS

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Inflammatory bowel disease (IBD) comprises Crohn’s disease (CD) and ulcerative colitis (UC) and is associated with neuropsychiatric symptoms like anxiety and depression. Both conditions strongly worsen IBD disease burden. In the present review, we summarize the current understanding of the pathogenesis of depression and anxiety in IBD. We present a stepwise cascade along a gut–immune–brain axis initiated by evasion of chronic intestinal inflammation to pass the epithelial and vascular barrier in the gut and cause systemic inflammation. We then summarize different anatomical transmission routes of gut-derived peripheral inflammation into the central nervous system (CNS) and highlight the current knowledge on neuroinflammatory changes in the CNS of preclinical IBD mouse models with a focus on microglia, the brain-resident macrophages. Subsequently, we discuss how neuroinflammation in IBD can alter neuronal circuitry to trigger symptoms like depression and anxiety. Finally, the role of intestinal microbiota in the gut–immune–brain axis in IBD will be reviewed. A more comprehensive understanding of the interaction between the gastrointestinal tract, the immune system and the CNS accounting for the similarities and differences between UC and CD will pave the path for improved prediction and treatment of neuropsychiatric comorbidities in IBD and other inflammatory diseases.

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“…It was revealed that cpMΦ are responsive to the absence of the microbiome. Additionally, gut microbiota influences the Aβ uptake of pvMΦ in 5xFAD mice (Sankowski et al, 2021 ). Further, CAMs in GF mice lack an appropriate response to immunostimulants typically characterized by expansion and expression of CD74.…”

Section: Influence Of the Microbiome On Cns Macrophagesmentioning

confidence: 99%

“…Further, CAMs in GF mice lack an appropriate response to immunostimulants typically characterized by expansion and expression of CD74. These findings suggest that the innate immune response depends on the presence of microbiota in the GIT and absence of the microbiome disrupts innate immunity (Sankowski et al, 2021 ). The gut microbiota has a major influence on CNS macrophages during development until adulthood and their metabolites govern the inflammatory response in the CNS, which is mediated by macrophages.…”

Section: Influence Of the Microbiome On Cns Macrophagesmentioning

confidence: 99%

Age-dependent effects of gut microbiota metabolites on brain resident macrophages

Hasavci

Blank

2022

Front. Cell. Neurosci.

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In recent years, development of age-related diseases, such as Alzheimer's and Parkinson's disease, as well as other brain disorders, including anxiety, depression, and schizophrenia have been shown to be associated with changes in the gut microbiome. Several factors can induce an alteration in the bacterial composition of the host‘s gastrointestinal tract. Besides dietary changes and frequent use of antibiotics, the microbiome is also profoundly affected by aging. Levels of microbiota-derived metabolites are elevated in older individuals with age-associated diseases and cognitive defects compared to younger, healthy age groups. The identified metabolites with higher concentration in aged hosts, which include choline and trimethylamine, are known risk factors for age-related diseases. While the underlying mechanisms and pathways remain elusive for the most part, it has been shown, that these metabolites are able to trigger the innate immunity in the central nervous system by influencing development and activation status of brain-resident macrophages. The macrophages residing in the brain comprise parenchymal microglia and non-parenchymal macrophages located in the perivascular spaces, meninges, and the choroid plexus. In this review, we highlight the impact of age on the composition of the microbiome and microbiota-derived metabolites and their influence on age-associated diseases caused by dysfunctional brain-resident macrophages.

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Commensal microbiota divergently affect myeloid subsets in the mammalian central nervous system during homeostasis and disease

Cited by 17 publications

References 62 publications

Trends in perivascular macrophages research from 1997 to 2021: A bibliometric analysis

Trends in perivascular macrophages research from 1997 to 2021: A bibliometric analysis

The Gut–Immune–Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease

Age-dependent effects of gut microbiota metabolites on brain resident macrophages

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