We establish compact presentability, i.e. the locally compact version of finite presentability, for an infinite family of tree almost automorphism groups. Examples covered by our results include Neretin's group of spheromorphisms, as well as the topologically simple group containing the profinite completion of the Grigorchuk group constructed by Barnea, Ershov and Weigel.We additionally obtain an upper bound on the Dehn function of these groups in terms of the Dehn function of an embedded Higman-Thompson group. This, combined with a result of Guba, implies that the Dehn function of the Neretin group of the regular trivalent tree is polynomially bounded.