Comment and reply on: The clinical significance of a positive Amnisure test in women with term labor with intact membranes

Martinuzzi, Kurt; Mariona, Federico G.

doi:10.3109/14767051003750900

Cited by 3 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From an initial 125 identified manuscripts, all the retrieved titles and abstracts were screened to discard repeated articles, leading to a total of 52 evaluable papers: 31 papers relating to Actim® PROM, 11 papers relating to AmniSure®, and 10 referring to both biomarkers. After a detailed process of selection (Figure 1 ), 35 papers were excluded because: they did not evaluate the specific biomarkers as a rapid test for PROM diagnosis [ 14 , 17 - 19 ], they studied the concentration of the biomarkers through pregnancy [ 11 , 20 - 23 ] or after an amniocentesis [ 24 ], they were solely studies of biochemical processes [ 25 , 26 ], they were adjunct to a genetic study [ 27 ], they comprised guidelines [ 9 ], they were review articles [ 8 , 13 , 28 , 29 ], they were a meta-analysis [ 30 ] or letter/comments on other articles [ 15 , 31 - 33 ], and they related to the application of the biomarker in obstetrics [ 18 , 23 ]. In two cases, the full text version of the studies were not available for consultation [ 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes

Palacio

Kühnert

Berger

et al. 2014

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundPremature rupture of the membranes (PROM) is most commonly diagnosed using physical examination; however, accurate decision making in ambiguous cases is a major challenge in current obstetric practice. As this may influence a woman’s subsequent management, a number of tests designed to assist with confirming a diagnosis of PROM are commercially available. This study sought to evaluate the published data for the accuracy of two amniotic fluid-specific biomarker tests for PROM: insulin-like growth factor binding protein-1 (IGFBP-1 – Actim® PROM) and placental alpha microglobulin-1 (PAMG-1 – AmniSure®).MethodsMain analysis included all PubMed referenced studies related to Actim® PROM and AmniSure® with available data to extract performance rates. To compare accuracy, a comparison of pooled indexes of both rapid tests was performed. Studies in which both tests were used in the same clinical population were also analysed. Membrane status, whether it was known or a suspected rupture, and inclusion or not of women with bleeding, were considered.ResultsAll the available studies published in PubMed up to April 2013 were reviewed. Data were retrieved from 17 studies; 10 for Actim® PROM (n = 1066), four for AmniSure® (n = 1081) and three studies in which both biomarker tests were compared directly. The pooled analysis found that the specificity and positive predictive value were significantly higher for AmniSure® compared with Actim® PROM. However, when 762 and 1385 women with known or suspected rupture of membranes, respectively, were evaluated, AmniSure® only remained significantly superior in the latter group. Furthermore, when the two tests were compared directly in the same study no statistically significant differences were observed. Remarkably, women with a history or evidence of bleeding were excluded in all four studies for AmniSure®, in two Actim® PROM studies and in two of the three studies reporting on both tests.ConclusionsNo differences were observed in the performance of the two tests in studies where they were used under the same clinical conditions or in women with known membrane status. Although AmniSure® performed better in suspected cases of PROM, this may need further analysis as exclusion of bleeding may not be representative of the real clinical presentation of women with suspected PROM.

show abstract

Section: Resultsmentioning

confidence: 99%

Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes

Palacio

Kühnert

Berger

et al. 2014

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…This was similar to the study by Kafali et al in which the mean vaginal fluid urea level was 34.6 mg/dl in the confirmed PROM group and 1.3 mg/dl in the control group, where the difference was statistically significant (p<0.001). 4,7 The cut off value of urea was calculated using ROC curve, it was found to be 8.55 mg/dl for the present study. In the study by Kafali et al the cut off was 12 mg/dl.…”

Section: Urea Levels In Vaginal Wash Fluidmentioning

confidence: 82%

“…The ideal test would be simple, noninvasive, rapid and cheap. 4 A new marker for PROM was suggested by Kafali et al, i.e. estimation of urea and creatinine in vaginal wash fluid.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of urea and creatinine levels in vaginal wash fluid for the diagnosis of premature rupture of membranes

Sharma¹,

Sharma²,

Agarwal³

2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Evaluation of urea and creatinine levels in vaginal wash fluid for the diagnosis of premature rupture of membranes.Methods: The study was conducted on150 pregnant patients, 50 in each group. Confirmed PROM and unconfirmed PROM. Per speculum examination was done to look for pooling, pH tested using the Pehanon paper and vaginal wash fluid was collected. Vaginal wash fluid urea and creatinine levels were tested by a kit based on spectrophotometry.Results: The mean urea levels were 26.35 mg/dl in the study Group 1 and 3.12 mg/dl in the control group. ROC curve was plotted and the cut off value of vaginal wash fluid urea was found to be 8.55 mg/dl. The vaginal wash fluid urea levels of >8.55 mg/dl detected PROM with a sensitivity, specificity, negative and positive predictive value of 100%. The mean creatinine levels were 0.62 mg/dl in study Group 1 and 0.20 mg/dl in the control group. ROC curve was plotted and the cut off value of vaginal wash fluid creatinine was found to be 0.405 mg/dl. Vaginal wash fluid creatinine levels detected PROM with a sensitivity of 76% and specificity of 100%. The negative predictive value and positive predictive values were 80.4% and 100%.Conclusions: Urea can be used as a definite marker of PROM and creatinine can be used as a supportive marker.

show abstract

“…The study design does not correspond to the bed-side situation where amniotic fluid is contaminated by vaginal discharge or other possible fluids like urine, semen or blood that may affect the test result causing false positives, if the test is too sensitive. A high rate of positive PAMG-1 test results has been found among patients with intact membranes and labor at term [18] and in patients with a short cervix [19]. This data has not been considered when analyzing the specificity of PAMG-1 test.…”

mentioning

confidence: 99%

Comment on: Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes and preventive tools for preterm birth

Rutanen

2011

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

Comment and reply on: The clinical significance of a positive Amnisure test in women with term labor with intact membranes

Cited by 3 publications

References 5 publications

Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes

Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes

Evaluation of urea and creatinine levels in vaginal wash fluid for the diagnosis of premature rupture of membranes

Comment on: Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes and preventive tools for preterm birth

Contact Info

Product

Resources

About