Comment faire le diagnostic et mieux comprendre les myopathies inflammatoires ? L’utilité des auto-anticorps

Sibilia, Jean; Chatelus, Emmanuel; Meyer, Alain; Gottenberg, Jacques-Éric; Sordet, Christelle; Goetz, Joëlle

doi:10.1016/j.lpm.2010.06.008

Cited by 26 publications

(9 citation statements)

References 77 publications

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“…Whether the only presence of anti-U1-snRNP and myositis has to be considered an incomplete form of MTCD or a true myositis, is still a matter of debate [ 128 , 129 ]. In addition, anti-U2-RNP [ 130 ], U5-RNP [ 131 ] and anti-U4/U6-RNP [ 132 ] have been described in patients with PM/SSc overlap syndrome.…”

Section: Myositis-associated Autoantibodiesmentioning

confidence: 99%

Bench to bedside review of myositis autoantibodies

et al. 2018

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Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been included, with the only exception of anti-Jo-1, into the 2017 Classification Criteria, thus perpetuating a clinical-serologic gap. The lack of homogeneous grouping based on the antibody profile deeply impacts the diagnostic approach, therapeutic choices and prognostic stratification of these patients. This review is intended to highlight the comprehensive scenario regarding myositis-related autoantibodies, from the molecular characterization and biological significance to target antigens, from the detection tools, with a special focus on immunofluorescence patterns on HEp-2 cells, to their relative prevalence and ethnic diversity, from the clinical presentation to prognosis. If, on the one hand, a notable body of literature is present, on the other data are fragmented, retrospectively based and collected from small case series, so that they do not sufficiently support the decision-making process (i.e. therapeutic approach) into the clinics.

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Section: Myositis-associated Autoantibodiesmentioning

confidence: 99%

Bench to bedside review of myositis autoantibodies

et al. 2018

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“…Elle appartient au groupe des myopathies inflammatoires idiopathiques [1,2]. L'atteinte cardiaque au cours de la DM est fréquente, elle est la troisième cause de décès après les néoplasies et les complications respiratoires.…”

Section: Discussionunclassified

“…La dermatomyosite (DM) fait partie des myopathies inflammatoires, dont le diagnostic positif repose sur des critères cliniques surtout musculaires et depuis une quinzaine d'années, sur la présence de certains auto-anticorps spécifiques de ces myosites [1]. L'atteinte cardiaque au cours des DM est fréquente, apparaissant essentiellement au cours de l'évolu-tion de la maladie.…”

Section: Pericarditis Revealing a Dermatomyositisunclassified

Péricardite révélatrice d’une dermatomyosite

et al. 2011

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“…Lors d'une lésion musculaire initiale (virale, médicamenteuse, toxique, ischémique), les auto-antigènes sont surexprimés, notamment dans les myoblastes en régénération, puis captés par les cellules dendritiques et présentés par les molécules HLA de classe I. Les lymphocytes T CD8 cytotoxiques sont ainsi activés, libérant des molécules (perforine et granzyme) qui vont induire la destruction de nouvelles fibres musculaires. C'est le principal mécanisme lésionnel dans les myopathies inflammatoires [4].…”

Section: Introduction Et Physiopathologieunclassified