Comment on: “Adverse Drug Reactions and Clinical Outcomes in Patients Initiated on Antiretroviral Therapy: A Prospective Cohort Study from Ethiopia”

Authors’ Reply to Cotton and Nicol’s Comment on “Adverse Drug Reactions and Clinical Outcomes in Patients Initiated on Antiretroviral Therapy: A Prospective Cohort Study from Ethiopia”

“…Cotton and Nicol for their letter [1]. They raise an important issue about maximizing the benefit and prolonging the efficacy of first-line antiretroviral therapy (ART) in sub-Saharan Africa during this time of rapid scaling-up to improve access to ART in the region [2].…”

“…We share the call of Drs Cotton and Nicol for rapid implementation of interventions to actively identify ADRs in patients who are initiated on ART [1]. However, it may be worth conducting a multicentre randomised controlled trial in resource-limited settings to test the effectiveness of various interventions to improve the detection and management of severe ART ADRs and thus improve treatment outcomes.…”