Comment on: COVID-19 vaccine-associated reactivation of uveitis

Sanjay, Srinivasan; Kawali, Ankush

doi:10.4103/ijo.ijo_2741_21

Cited by 4 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anterior uveitis has also been reported following COVID-19 vaccination. [ 5 , 6 ] In a series assessing the COVID-19 vaccination and uveitis, Ferrand et al . [ 6 ] found that the majority were anterior uveitis and had a previous history of anterior uveitis, and 15.8% of cases needed an increase in their systemic therapy.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination, dengue hepatitis, and recurrent unilateral anterior uveitis

Sanjay

Kawali

Mahendradas

2023

Indian Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

A 36-year-old Asian Indian male presented with redness and pain in his right eye of 1 week duration. He was diagnosed to have right acute anterior uveitis and had a history of being admitted at a local hospital for dengue hepatitis a month earlier. He had been on adalimumab 40 mg three weekly once and oral methotrexate 20 mg/week for human leucocyte antigen (HLA) B27 spondyloarthropathy and recurrent anterior uveitis. Our patient had re-activation of his anterior chamber inflammation on three distinct occasions: first, 3 weeks following recovery from coronavirus disease 2019 (COVID-19), the second after the second dose of COVID-19 vaccination, and the third after recovery from dengue fever-associated hepatitis. We propose molecular mimicry and bystander activation as the postulated mechanisms for the re-activation of his anterior uveitis. In conclusion, patients with auto-immune diseases can have recurrent ocular inflammation following COVID-19 or its vaccination or dengue fever as seen in our patient. The anterior uveitis is usually mild and responds to topical steroids. Additional immuno-suppression may not be needed. Mild ocular inflammation following vaccination should not deter individuals from getting COVID-19 vaccination.

show abstract

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination, dengue hepatitis, and recurrent unilateral anterior uveitis

Sanjay

Kawali

Mahendradas

2023

Indian Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Noninfectious uveitis was reported to be higher following SARS-CoV-2 infection, but a recent claims-based analysis suggests that this may be related to the preexisting comorbidities and immunosuppressive treatments 52 . Reactivation of uveitis with vaccination is possible but proof of causality remains complex 53 . This includes keratouveitis related to herpes zoster reactivation but affects many other cranial nerves as carefully reviewed and referenced in 54 .…”

Section: Autoimmunementioning

confidence: 99%

“…52 Reactivation of uveitis with vaccination is possible but proof of causality remains complex. 53 This includes keratouveitis related to herpes zoster reactivation but affects many other cranial nerves as carefully reviewed and referenced in. 54 There is some evidence for vitritis that can be associated with uveitis.…”

Section: Uveitis and Vitritismentioning

confidence: 99%

Neuro-Ophthalmic Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Related Infection and Vaccination

Petzold

2022

Asia-Pacific Journal of Ophthalmology

View full text Add to dashboard Cite

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a unique opportunity to study the effects of infection and vaccination on disease. The year 2020 was dominated by infection and its consequences. The year 2021 was dominated by vaccination and its consequences. It will still take several years for full maturation of databases required for robust epidemiological studies. Therefore, this review on the implications for neuro-ophthalmology draws on resources presently available including reported adverse reactions to vaccination. Illustrative clinical cases are presented. The spectrum of pathology following infection with SARS-CoV-2 falls into 4 main categories: autoimmune, vascular, sequelae of brain damage, and miscellaneous. This review is exhaustive, but the most common conditions discussed relate to headaches and associated symptoms; vertigo, diplopia, and nystagmus; vascular complications of the eye and brain; cranial nerve (mono-)neuropathies; photophobia, ocular discomfort, and optic neuritis. Of the 36 main adverse reactions reviewed, vaccine-induced immune thrombotic thrombocytopenia is a novel complication requiring specific hematological management. Updated diagnostic criteria are summarized. It is relevant to remember taking a medication history because of side effects and to recognize the relevance of comorbidities. The clinical assessment can frequently be performed virtually. Consensus recommendations on telemedicine and the virtual assessment are summarized in a practical and compressed format. The review concludes with an epidemiological tetralogy to interrogate, in future studies, associations with (1) SARS-CoV-2 pandemic infection, (2) SARS-CoV-2 worldwide vaccination, and (3) the possibility of a rebound effect of infections in the pandemic aftermath.

show abstract

“…The reported ocular side effects include episcleritis, scleritis, uveitis, multifocal choroiditis, acute macular neuroretinopathy, Vogt–Koyanagi–Harada disease (VKH), central serous chorioretinopathy (CSCR), non-arteritic anterior ischemic optic neuropathy, herpes zoster reactivation, and acute retinal necrosis. [ 1 2 3 4 5 ] Occurrence of anterior uveitis following first or second dose of COVID-19 vaccination has been reported. [ 1 3 ]…”

mentioning

confidence: 99%

“…[ 1 2 3 4 5 ] Occurrence of anterior uveitis following first or second dose of COVID-19 vaccination has been reported. [ 1 3 ]…”

mentioning

confidence: 99%

COVID-19 vaccination and recurrent anterior uveitis

Sanjay

Yathish

Singh

et al. 2022

Indian Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

A 35-year-old Asian Indian female previously diagnosed with bilateral anterior uveitis and on oral methotrexate developed bilateral anterior uveitis following first/second dose of coronavirus disease 2019 (COVID-19) vaccination. She had skipped her weekly dose of oral methotrexate following first dose of vaccination. Following the second dose, she reduced her oral methotrexate from 25 to 15 mg on her own, but did not stop like the previous occasion. She had extensive workup for her uveitis in the past with only positive severe acute respiratory syndrome coronavirus (SARS-CoV-2) antibodies. She developed unilateral anterior uveitis after she had COVID-19 in July 2022, which resolved with topical steroids and continuation of immunosuppression. This report illustrates that COVID-19 or its vaccination may presumably play a role in triggering the immune system and can cause recurrent ocular inflammation even in the absence of an extraocular inflammation.

show abstract

Comment on: COVID-19 vaccine-associated reactivation of uveitis

Cited by 4 publications

References 13 publications

COVID-19 vaccination, dengue hepatitis, and recurrent unilateral anterior uveitis

COVID-19 vaccination, dengue hepatitis, and recurrent unilateral anterior uveitis

Neuro-Ophthalmic Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Related Infection and Vaccination

COVID-19 vaccination and recurrent anterior uveitis

Contact Info

Product

Resources

About