Comment on “Cutting Edge: Inhibition of NF-κB-Mediated TSLP Expression by Retinoid X Receptor”

Gericke, Janine; Gamlieli, Anat; Weiss, Kathrin; Rühl, Ralph

doi:10.4049/jimmunol.182.1.3-a

Cited by 3 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The RXR agonist 9‐ cis‐ retinoic acid was shown to be a negative regulator of TSLP expression in airway epithelial cells through direct inhibition of NF‐κB signaling, not through direct binding to the TSLP gene promoter 24 . However, whether inhibition of TSLP expression by RXR is NF‐κB dependent is still controversial; another group used more selective synthetic RXR or retinoic acid receptor agonists in mice for NF‐κB and TSLP gene expression analysis in the skin and obtained opposite results 25 …”

Section: Thymic Stromal Lymphopoietin and Its Receptormentioning

confidence: 99%

Thymic stromal lymphopoietin

Geha

2010

Annals of the New York Academy of Sciences

214

198

View full text Add to dashboard Cite

Thymic stromal lymphopoietin (TSLP) is an epithelial cell derived cytokine expressed in skin, gut, lungs and thymus. TSLP signals via TSLPR, a heterodimer of the IL-7 receptor alpha chain (IL-7Rα) and the TSLP receptor chain (TSLPR), which is closely related to the common receptor-γ chain (γc), expressed on a wide range of cell types in the adptaive and innate immune system. TSLP exerts profound influence on the polarization of dendritic cells (DCs) to drive T helper (Th) 2 cytokine production. It also directly promotes T cell proliferation in response to T cell receptor (TCR) activation, and Th2 cytokine production. TSLP also supports B cell expansion and differentiation. TSLP further amplifies Th2 cytokine production by mast cells and NKT cells. These properties confer on TSLP a critical role in driving Th2 mediated inflammation. This role is supported by the finding that TSLP expression is up-regulated in keratinocytes of atopic dermatitis (AD) skin lesions and in bronchial epithelial cells in asthma.

show abstract

Section: Thymic Stromal Lymphopoietin and Its Receptormentioning

confidence: 99%

Thymic stromal lymphopoietin

Geha

2010

Annals of the New York Academy of Sciences

214

198

View full text Add to dashboard Cite

show abstract

“…Moreover, topical application of active vitamin D3 or the low‐calcemic analogue MC903 leads to elevated TSLP production from normal keratinocytes . The RXR agonist 9‐cis‐retinoic acid was shown to inhibit TSLP expression in airway epithelial cells via directly inhibiting NF‐κB ; however, the role of NF‐κB remain controversial in this mechanism as another group used more selective synthetic RXR agonists and found opposite results . Interestingly, capsazepine, a widely used transient receptor potential cation channel, subfamily V, member 1 (TRPV1) antagonist was shown recently to completely inhibit the dsRNA‐induced epithelial TSLP and TNF‐α gene expression .…”

Section: Molecular Regulation Of Thymic Stromal Lymphopoietin Expressionmentioning

confidence: 99%

Function and mechanisms of TSLP/TSLPR complex in asthma and COPD

Redhu

Gounni

2011

Clin Experimental Allergy

View full text Add to dashboard Cite

Thymic stromal lymphopoietin (TSLP) is a key pro-allergic cytokine that has recently been linked to chronic airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). High levels of TSLP were detected in bronchial mucosa of asthma and COPD patients suggesting TSLP's biological role beyond a signature 'Th2-favoring' or 'pro-allergic cytokine'. Besides inflammatory cells, airway structural cells produce and are targets of TSLP suggesting a potential autocrine loop that may have a profound effect on local inflammatory response and airway remodelling. This review sums up diverse mechanisms that mediate TSLP/TSLP receptor-signalling network in chronic airway diseases.

show abstract