Comment on “Development of Correlations for Describing Solute Transfer into Acyclic Alcohol Solvents Based on the Abraham Model and Fragment-Specific Equation Coefficients”

Reply to comments of Endo and Goss concerning “development of correlations for describing solute transfer into acyclic alcohol solvents based on the Abraham model and fragment-specific equation coefficients”

“…N C is subtracted with 1 so that the second expression becomes equivalent to the LSER equation for methanol. As Endo and Goss show in their paper [1] Eqs. (1) and (2) do provide very good mathematical descriptions for the observed log K and log P data for solutes dissolved in anhydrous alcohol solvents.…”

“…We appreciate the comments and observations of Endo and Goss [1] regarding our initial examination [2] of splitting the Abraham model coefficients into fragment-specific values that could be combined to develop correlation expressions for additional solvents. Endo and Goss correctly note that it is possible to describe mathematically the logarithm of the experimental gas-to-anhydrous alcohol partition coefficient (log K) and logarithm of the water-toanhydrous alcohol partition coefficient (log P) with fewer curve-fit parameters.…”

Applications of Polyparameter Linear Free Energy Relationships in Environmental Chemistry

“…They assumed that system parameters can be obtained by summing empirically fitted fragment constants for CH 3 , CH 2 , CH, C, and OH. Further investigation, however, is needed to elucidate whether such a fragment approach can be extended to the prediction of solvent parameters for other types of solvents. , So far, no general model is in sight for prediction of all system parameters for a given system.…”