Comment on “Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome”

Fenske, M.

doi:10.1016/j.jpsychores.2006.03.009

Journal of Psychosomatic Research

2006

DOI: 10.1016/j.jpsychores.2006.03.009

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Comment on “Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome”

M. Fenske

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2014

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Sources of Variability in Metabolite Measurements from Urinary Samples

et al. 2014

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BackgroundThe application of metabolomics in epidemiological studies would potentially allow researchers to identify biomarkers associated with exposures and diseases. However, within-individual variability of metabolite levels caused by temporal variation of metabolites, together with technical variability introduced by laboratory procedures, may reduce the study power to detect such associations. We assessed the sources of variability of metabolites from urine samples and the implications for designing epidemiologic studies.MethodsWe measured 539 metabolites in urine samples from the Navy Colon Adenoma Study using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectroscopy (GC-MS). The study collected 2–3 samples per person from 17 male subjects (age 38–70) over 2–10 days. We estimated between-individual, within-individual, and technical variability and calculated expected study power with a specific focus on large case-control and nested case-control studies.ResultsOverall technical reliability was high (median intraclass correlation = 0.92), and for 72% of the metabolites, the majority of total variance can be attributed to between-individual variability. Age, gender and body mass index explained only a small proportion of the total metabolite variability. For a relative risk (comparing upper and lower quartiles of “usual” levels) of 1.5, we estimated that a study with 500, 1,000, and 5,000 individuals could detect 1.0%, 4.5% and 75% of the metabolite associations.ConclusionsThe use of metabolomics in urine samples from epidemiological studies would require large sample sizes to detect associations with moderate effect sizes.

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Sources of Variability in Metabolite Measurements from Urinary Samples

et al. 2014

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Comment on “Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome”

Cited by 1 publication

References 12 publications

Sources of Variability in Metabolite Measurements from Urinary Samples

Sources of Variability in Metabolite Measurements from Urinary Samples

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