Comment on Epitaxial Relationships between Uric Acid Crystals and Mineral Surfaces:  A Factor in Urinary Stone Formation

Grover, Phulwinder K.; Ryall, Rosemary L.

doi:10.1021/la0509293

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…However, they also recognized that uric acid may promote calcium oxalate crystallization by another mechanism in human urine [6–8]. They proposed a “salting out” mechanism [2, 9]. Salting out is a decrease in solubility of a non-electrolyte with increasing concentrations of electrolyte, causing the former to precipitate from solution.…”

Section: Does Hyperuricosuria Promote Calcium Stones?mentioning

confidence: 99%

Treatment of calcium nephrolithiasis in the patient with hyperuricosuria

Arowojolu

Goldfarb

2014

J Nephrol

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Nearly one-third of patients with calcium stones have hyperuricosuria. In vitro studies and clinical trials have investigated the relationship between uric acid and calcium stones, but the association between hyperuricosuria and calcium stone formation in patients is still being debated. Uric acid appears to cause salting out of calcium oxalate in human urine. However, the importance of this in vitro phenomenon to the proposed association is not supported in cross-sectional observational studies. A small placebo-controlled randomized clinical trial showed that allopurinol decreased the rate of recurrent calcium oxalate calculi in patients with hyperuricosuria and normocalciuria. An assessment of the effect of combination therapy of allopurinol with indapamide showed no additive effect. Allopurinol may have antioxidant effects that are responsible for its reducing calcium stone formation, which are independent of xanthine oxidase inhibition. In addition, a newer xanthine oxidoreductase inhibitor, febuxostat, may also be effective in the prevention of calcium stones, as it reduces urinary uric acid excretion.

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Section: Does Hyperuricosuria Promote Calcium Stones?mentioning

confidence: 99%

Treatment of calcium nephrolithiasis in the patient with hyperuricosuria

Arowojolu

Goldfarb

2014

J Nephrol

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show abstract

“…Urinary stone, one of the most painful urologic disorders, is the product of pathological biomineralization, has beset people for centuries [1][2][3]. It reported, in the United States alone, kidney stones account for over one million hospital admissions per year, and 12% of men and 4.5% of women will develop a stone by the age of 70 [4,5].…”

Section: Introductionmentioning

confidence: 99%

Biogenic synthesis of calcium oxalate crystal by reaction of calcium ions with spinach lixivium

Xie

et al. 2010

Colloids and Surfaces B: Biointerfaces

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Comment on Epitaxial Relationships between Uric Acid Crystals and Mineral Surfaces: A Factor in Urinary Stone Formation

Cited by 2 publications

References 13 publications

Treatment of calcium nephrolithiasis in the patient with hyperuricosuria

Treatment of calcium nephrolithiasis in the patient with hyperuricosuria

Biogenic synthesis of calcium oxalate crystal by reaction of calcium ions with spinach lixivium

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