Comment on IWGDF ulcer prevention guidelines

Nickerson, D. Scott; Barrett, Stephen L.

doi:10.1002/edm2.169

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Peptic ulcers, upper gastrointestinal tumor, and acute gastric mucosal lesions were the most common [21]. This study showed that the most common causes of acute nonvaricose upper gastrointestinal bleeding were peptic ulcer, acute gastric mucosal lesion, and upper gastrointestinal tumor, and other causes were esophagocardiac mucosal tear syndrome [22]. The etiological distribution is similar to that reported in related studies.…”

Section: Discussionsupporting

confidence: 84%

A Cohort Study to Compare Effects between Ulcer- and Nonulcer-Related Nonvariceal Upper Gastrointestinal Bleeding

Nian

Wang

et al. 2022

Applied Bionics and Biomechanics

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Objective. The aim of this study was to better understand the characteristics and etiology of acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) in recent years in this region and to provide evidence-based medical evidence. Methods. 100 patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) who met the clinical diagnostic criteria of ANVUGIB admitted to Suzhou First People’s Hospital from January 2017 to December 2021 were analyzed, as well as the age difference and change rule. According to age, 100 patients were divided into young (18-39 years), middle-aged (40-59 years), and elderly (60 years and above), and the differences in the three groups were compared. The etiology was confirmed by endoscopic examination and was recorded one by one in a well-designed ANVUGIB case data registration form. Statistical software SPSS 23.0 was used for analysis. Results. Gastric ulcer was the main cause in the elderly group (50.0%), duodenal ulcer was the main cause in the middle and young groups, and gastrointestinal cancer (7.1%) and marginal ulcer (2.3%) in the elderly group were higher than those in the young group. Nonsteroidal anti-inflammatory drugs (52.3%) were the main inducement in the elderly group, which was significantly higher than in the middle-aged group (13.1%) and the young group (5%) ( P < 0.01 ). Drinking, fatigue, and emotional excitement led to a higher proportion in the middle-aged group and the young group, in comparison to the elderly group ( P < 0.01 ). Conclusion. Peptic ulcer is the most common cause of acute nonvariceal upper gastrointestinal bleeding, followed by acute gastric mucosal lesions and upper digestive system tumors, compared with nonulcer.

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Section: Discussionsupporting

confidence: 84%

A Cohort Study to Compare Effects between Ulcer- and Nonulcer-Related Nonvariceal Upper Gastrointestinal Bleeding

Nian

Wang

et al. 2022

Applied Bionics and Biomechanics

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“…DFU refers to foot infections, epidermal wounds or tissue damage caused by aberrant nerve conduction velocity and reflex and varying degrees of vascular lesions in the distal lower extremity 5,6 . Evidently, its pathophysiology involves ulceration and profound tissue destruction caused by lower limb ischemic peripheral vascular disease, peripheral neuropathy and infection, which often requires amputation surgery due to osteomyelitis 5,6 . The deterioration of DFUs is responsible for more than 85% of amputations in diabetic individuals 7–9 .…”

Section: Introductionmentioning

confidence: 99%

“… 5 , 6 Evidently, its pathophysiology involves ulceration and profound tissue destruction caused by lower limb ischemic peripheral vascular disease, peripheral neuropathy and infection, which often requires amputation surgery due to osteomyelitis. 5 , 6 The deterioration of DFUs is responsible for more than 85% of amputations in diabetic individuals. 7 , 8 , 9 Of DFUs, ~50% or more become infected, wherein 20% of moderate‐to‐severe infections result in lower extremity amputation.…”

Section: Introductionmentioning

confidence: 99%

Metabolic dysfunction‐associated fatty liver disease in the elderly with diabetic foot ulcers: A longitudinal cohort study

Zhang,

Lin,

Huang

et al. 2023

International Wound Journal

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This study aimed to explore the association between metabolic‐associated fatty liver disease (MAFLD) and ulcer recurrence risk in patients with diabetic foot ulcers (DFUs) through an ambispective longitudinal cohort. From December 2013 to December 2022, a total of 482 inpatients with DFUs (PEDIS grade 3 and above with a severe infection) were eligible for inclusion in this study. This was an ambispective longitudinal cohort study. All participants were followed up every 6 months for 9 years with a median of 36 months. According to whether having MAFLD or not, all subjects were placed into two groups: non‐MAFLD (n = 351) and MAFLD (n = 131). The association between MAFLD and ulcer recurrence in patients with DFUs was then evaluated through multivariate Cox regression analysis, stratified analyses and Kaplan–Meier survival analysis. Throughout the follow‐up period, out of 482 subjects with DFUs, 68 had ulcer recurrence (14.1%). Three Cox regression models were established for data analyses. In the model I (unadjusted), MAFLD was significantly associated with the ulcer recurrence rate in patients with DFUs (HR = 1.79; 95% CI = 1.097–2.92; p = 0.02). Model II (adjusted model I with gender and age) (HR = 1.781; 95% CI = 1.09–2.912; p = 0.021) and model III (adjusted model II with CVD, duration of diabetes and Cr.) (HR = 1.743; 95% CI = 1.065–2.855; p = 0.027) also showed that MAFLD was significantly related to the ulcer recurrence risk in patients with DFUs, respectively. Stratified analysis indicated that subjects aged ≥60 had a greater risk of ulcer recurrence in MAFLD than in non‐MAFLD (HR = 2.31; 95% CI = 1.268–4.206; p = 0.006). Kaplan–Meier survival curve analysis showed that ulcer recurrence rate had a significant association with MAFLD (log‐rank, p = 0.018). This study indicated a close association between ulcer recurrence risk and MAFLD in patients with DFUs, especially in the elderly (aged ≥60). Therefore, special attention should be paid to the elderly with both DFUs and MAFLD because they have a higher ulcer recurrence rate than other general populations in routine clinical practice.

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Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review

Zhang,

Yang,

et al. 2023

World J Diabetes

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The complication of diabetes, which is known as diabetic foot ulcer (DFU), is a significant concern due to its association with high rates of disability and mortality. It not only severely affects patients’ quality of life, but also imposes a substantial burden on the healthcare system. In spite of efforts made in clinical practice, treating DFU remains a challenging task. While mesenchymal stem cell (MSC) therapy has been extensively studied in treating DFU, the current efficacy of DFU healing using this method is still inadequate. However, in recent years, several MSCs-based drug delivery systems have emerged, which have shown to increase the efficacy of MSC therapy, especially in treating DFU. This review summarized the application of diverse MSCs-based drug delivery systems in treating DFU and suggested potential prospects for the future research.

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Comment on IWGDF ulcer prevention guidelines

Cited by 3 publications

References 14 publications

A Cohort Study to Compare Effects between Ulcer- and Nonulcer-Related Nonvariceal Upper Gastrointestinal Bleeding

A Cohort Study to Compare Effects between Ulcer- and Nonulcer-Related Nonvariceal Upper Gastrointestinal Bleeding

Metabolic dysfunction‐associated fatty liver disease in the elderly with diabetic foot ulcers: A longitudinal cohort study

Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review

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