Almost a fifth of South Africans fear that vaccines are unsafe. South Africa has indeed been a target of many anti-vaccination lobbying websites with claims and concerns regarding safety, the risk of adverse events, thimerosal, idiopathic illnesses including autism, and ‘vaccine-injured’ children. This seems to have contributed to the anti-immunization rumors and resistance within South Africa. Unfortunately, South African scientist, Timothy Noakes, has disseminated several expressions, claims, retweets, and re-publications about vaccines that are not based on truthful, accurate or up to date scientific information. This misinformation about vaccines that have been expressed, shared, and or spread can be deemed as irresponsible, unscientific, and a potential public health threat. Such information spread online can have and has had a major impact on critical thinking, vaccine acceptance, parental decisions, and even disease outbreaks. Upon analysis of Tim Noakes’ social media, there is a substantial amount of evidence for concern. From June to December 2019 there was a statistically significant increase in the number of followers Noakes gained that also aligned with anti-vaccine views. As for the content that Noakes himself has shared and expressed, 90% were Anti-Vaccine in nature, while only 10% were Pro-Vaccine. The potential maximum number of exposures to this anti-vaccine misinformation and rhetoric are in the millions, with approximately 3 million exposures in 2019 alone and 4 million in total from 2014 to 2019. The claim that Noakes has not shared anti-vaccine misinformation is terribly weak and not based on the evidence. Continuing to spread this misinformation is a complete contradiction to what Noakes stands for, what others in his profession stand for, and what his own country’s regulatory body, as well as international organizations, stand for.This paper investigates common anti-vaccine misinformation shared by Tim Noakes and is also a social media analysis that covers anti-vaccine tropes and content. This paper also doubles as a literature review on the spread of misinformation in general, and more specifically, anti-vaccine misinformation. A separate section is dedicated to the topic of cancer misinformation which demonstrates the convergence between misleading cancer and vaccine ideologies.The conclusions made in this paper are not all conclusive and there is room for flexibility — what is written is also meant to stimulate further input and discussion. Given the personal and emotive nature of the topic, it should be emphasized that what is written is with a non-malicious intent and should be perceived as in the interest of public health and online safety.This case with Tim Noakes acts as a vehicle to highlight and learn more about several aspects of vaccine hesitancy, the anti-vaccine movement, social media, and misinformation in general.