Commentary: Appraisal of histopathological correlations in Vogt-Koyanagi-Harada uveitis

Murugan, S Bala

doi:10.4103/ijo.ijo_409_19

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…During acute uveitis, the subretinal fluid is made up of eosinophilic proteinaceous material. There is diffuse infiltration of lymphocytes, epithelioid histiocytes, and multinucleated giant cells, similar to features of the choroidal stromal disease [31]. Dalen-Fuchs nodules can be formed by the accumulation of hyperplastic retinal pigment epithelium (RPE), macrophages, epithelioid cells, and lymphocytes between the RPE and Bruch's membrane [32,33].…”

Section: Histopathological Featuresmentioning

confidence: 87%

Vogt-Koyanagi-Harada Disease: Current Diagnosis and Management

Goyal,

Shah,

Anantharaman

et al. 2024

Uveitis - Basics, Diagnosis, and Treatment

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Vogt-Koyanagi-Harada (VKH) disease is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin, and hair. This disease is mainly a T1 lymphocyte-mediated aggression to melanocytes. The availability of new investigational methods has improved our knowledge of the pathogenesis, clinical approach, diagnosis, and management of VKH disease. The disease has an acute onset of bilateral blurred vision with hyperemia in the absence of prior ocular trauma or any previous intraocular surgery. The chronic phase comprises of ocular and integumentary system pigmentary changes. Ocular findings may be accompanied by meningismus, hearing impairment, and skin lesions in a variable proportion of patients. Prompt diagnosis with early, aggressive, and long-term treatment of high-dose corticosteroids ensures good visual outcomes. The aim of this chapter is to present the clinicopathology, classification, recent imaging, investigations, and management of VKH disease.

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Section: Histopathological Featuresmentioning

confidence: 87%

Vogt-Koyanagi-Harada Disease: Current Diagnosis and Management

Goyal,

Shah,

Anantharaman

et al. 2024

Uveitis - Basics, Diagnosis, and Treatment

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“…22 In our case, these lesions did not agree with these classical distribution but were instead mainly concentrated in the posterior pole and midperiphery region. Murugan et al 23 have highlited that sometimes atrophic lesions seen in the convalescent stage can produce similar lesions which erroneously may be confused with D-F. Histopathologically, such nodules usually reveal focal RPE loss with chorioretinal adhesions. However, they also conclude that even these erroneous lesions are mostly found in the peripheral retina which is again not congruent with our finding.…”

Section: F I G U R Ementioning

confidence: 99%

A rare entity: Sympathetic ophthalmia presumably after blunt trauma to the phthisical eye and optical coherence tomography angiography metrics to monitor response to treatment

Khatri

Timalsena

Khatri

et al. 2019

Clinical Case Reports

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A blunt trauma to a phthisical eye may elicit sympathetic ophthalmia. Non invasive imaging such as use of optical coherence tomography and angiography metrics of the retinal and choroidal vasculature can help monitor response to the treatment. K E Y W O R D Sangiography, autoantigens, imaging, ocular wounds, optical coherence tomography and angiography, phthisis, sympathetic ophthalmia, uveitis 150 | KHATRI eT Al.How to cite this article: Khatri A, Timalsena S, Khatri BK, et al. A rare entity: Sympathetic ophthalmia presumably after blunt trauma to the phthisical eye and optical coherence tomography angiography metrics to monitor response to treatment. Clin Case Rep.

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