Commentary: Leaflet fluttering of bioprosthetic valve—Does it matter?

Obrist, Dominik; Carrel, Thierry

doi:10.1016/j.xjon.2020.10.009

Cited by 4 publications

(7 citation statements)

References 4 publications

(7 reference statements)

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“…Driven by ongoing curiosity and armed with new data from Leonardo , we reported our findings through a series of preprints and publications (Scotten and Walker 2004; Scotten et al 2006, 2011, 2014, 2015 preprint versions 1-4, 2019-2020, 2022; Chaux et al 2016; Deutsch et al 2018; Lee et al 2020; Lee et al 2021). In a recent broader application of our investigative technology, results from in silico computational modeling and in vitro experimental studies confirmed or verified the characteristics of leaflet spatial oscillations in bioprosthetic valves (flutter) throughout the open period of the cardiac cycle Lee et al 2020 and prompted peer commentary (Lee et al 2021; Carpenter 2021; Obrist and Carrel 2021; Barret et al 2023).…”

Section: Introductionmentioning

confidence: 73%

“…Aforementioned conditions and settings used in this study are applicable to Figure 1 and are related to fluid-structure interaction (FSI) studies and associated boundary conditions [11–15]. Also, in comparing results from a computational model with results from the pulse duplicator, experimental outcomes showed close agreement [11, 12, 14, 15]. Test valves are listed in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…Over time, progressive adaptations to the pulse duplicator apparatus have been reported [1][2][3][4][5][6][7][8][9][10][11][12]. This included the optical measurement of valve kinematics and in silico evaluations [3][4][5][6][7][8][9][10][11][12][13][14][15]. Aforementioned conditions and settings used in this study are applicable to Figure 1 and are related to fluid-structure interaction (FSI) studies and associated boundary conditions [11][12][13][14][15].…”

Section: Pulse Duplicator Experiments and Computational Modelingmentioning

confidence: 99%

“…This included the optical measurement of valve kinematics and in silico evaluations [3][4][5][6][7][8][9][10][11][12][13][14][15]. Aforementioned conditions and settings used in this study are applicable to Figure 1 and are related to fluid-structure interaction (FSI) studies and associated boundary conditions [11][12][13][14][15]. Also, in comparing results from a computational model with results from the pulse duplicator, experimental outcomes showed close agreement [11,12,14,15].…”

Section: Pulse Duplicator Experiments and Computational Modelingmentioning

confidence: 99%

“…Driven by ongoing curiosity and armed with new data from Leonardo, we reported our findings through a series of preprints and publications [4][5][6][7][8][9][10][11][12]. In a recent broader application of our investigative technology, results from in silico computational modeling and in vitro experimental studies provided validation of the characteristics of bioprosthetic valve leaflet flutter along with invited peer commentary [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Canary in the cardiac-valve coal mine. Flow velocity and inferred shear during prosthetic valve closure –predictors of blood damage and clotting

Scotten¹,

Siegel²,

Blundon

et al. 2022

Preprint

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Objective: To demonstrate a clear link between predicted blood shear forces during valve closure and thrombogenicity that explains the thrombogenic difference between tissue and mechanical valves and provides a practical metric to develop and refine prosthetic valve designs for reduced thrombogenicity. Methods: Pulsatile and quasi-steady flow systems were used for testing. The instantaneous valve flow area was measured using analog opto-electronics with output calibrated to the projected dynamic valve area. Flow velocity during the open and closing periods was determined from the instantaneous volumetric flow rate divided by valve flow area. For the closed valve interval, data obtained from quasi-steady back pressure/flow tests was used. Performance ranked by the derived valvular flow velocity and maximum negative closing flow velocity for all valves is experimental evidence for potential clinical thrombogenicity. Clinical, prototype and control valves were tested. Results: Establishment of a link between blood shear force and thrombogenicity led to optimization of a prototype mechanical bi-leaflet valve. The flow velocity metric was used to empirically design a 3-D printed model (BV3D) for softer valve closure dynamics which implicates reduced thrombogenic potential. Conclusions: The relationship between leaflet geometry, flow velocity and predicted shear at valve closure illuminated an important source of prosthetic valve thrombogenicity. With an appreciation for this relationship and based on our experiment generated comparative data, we achieved optimization of valve prototypes with potential for reduced thrombogenicity.

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Section: Introductionmentioning

confidence: 73%

Section: Methodsmentioning

confidence: 99%

Section: Pulse Duplicator Experiments and Computational Modelingmentioning

confidence: 99%

Section: Pulse Duplicator Experiments and Computational Modelingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Canary in the cardiac-valve coal mine. Flow velocity and inferred shear during prosthetic valve closure –predictors of blood damage and clotting

Scotten¹,

Siegel²,

Blundon

et al. 2022

Preprint

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Analysis of Fluid–Structure Interaction Mechanisms for a Native Aortic Valve, Patient-Specific Ozaki Procedure, and a Bioprosthetic Valve

Fringand,

Mace,

Cheylan

et al. 2024

Ann Biomed Eng

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Self-excited flapping motion of wall-mounted valvular leaflets in a three-dimensional channel flow

Wang,

Nitti,

de Tullio

2024

Physics of Fluids

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The onset of flow-induced oscillations in valve-like configurations remains not completely understood, despite the wide relevance in fluid transport across human physiology and various industrial applications. The present work explores the excitation mechanisms of self-sustained oscillation with key operating parameters in a general-purpose configuration by means of high-fidelity simulations. The investigation is carried out with a partitioned framework that resolves the fluid field by a finite-difference fractional step scheme, discretizes the structural domain via an isogeometric method, and considers an immersed boundary forcing through the interpolation/spreading kernel built by moving-least squares. Our findings confirm the onset of flapping motion in valvular shells, jointly influenced by geometric parameters, structural properties, and flow conditions. Specifically, at a Reynolds number (Re) of 800 and shell aspect ratio of 1.0, a critical reduced velocity exists at around 6, bifurcating static and periodic oscillation modes. After this criterion, flexible shells flutter in the third-plate-mode natural frequency, with oscillation amplitudes approaching an asymptotic value, coupled with intensified vortex shedding, as the reduced velocity increases. Re mainly imparts a destabilizing effect on the fluid-shell system; a lower Re suppresses flow-induced vibrations through viscous dissipation, while a higher Re introduces three-dimensional complexities, asymmetrical oscillations, and quasi-periodicity in the flapping dynamics, especially within the critical regime of reduced velocity. The impact of shell aspect ratio is intricate; in contrast, the case with an aspect ratio of 1.3 displays more intensive flapping motion compared to the reference case of 1.0, whereas further increasing to 1.6 mainly shows stabilizing effects in the shell dynamics.

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Commentary: Leaflet fluttering of bioprosthetic valve—Does it matter?

Cited by 4 publications

References 4 publications

Canary in the cardiac-valve coal mine. Flow velocity and inferred shear during prosthetic valve closure –predictors of blood damage and clotting

Canary in the cardiac-valve coal mine. Flow velocity and inferred shear during prosthetic valve closure –predictors of blood damage and clotting

Analysis of Fluid–Structure Interaction Mechanisms for a Native Aortic Valve, Patient-Specific Ozaki Procedure, and a Bioprosthetic Valve

Self-excited flapping motion of wall-mounted valvular leaflets in a three-dimensional channel flow

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