“…This point is of paramount importance and should be strongly considered in the surgical plan. In fact, because the patients who underwent combined prosthetic valve replacement would became high-risk surgical patients compared with those patients who received an isolated prosthesis replacement, 3 considering that the incidence of embolic and bleeding events are similar between the 2 types of prosthesis 1,5,6 and in light of the most recent evidence regarding the promising results of mitral ViV procedures, 4,7 surgeons must not depart from the standard indication of offering a mechanical prosthesis for young patients and should consider the biological prosthesis only for those who refuse or who do not tolerate the anticoagulant therapy and in cases of isolated mitral valve replacement that would better tolerate the surgical risk of reoperation in the future.…”