Major research breakthroughs over the past 30 years in the field of psychoactive substance use prevention research have served to: (1) improve understanding of pharmacological effects on the central nervous system and the health and social consequences of the use of these substances, particularly for children and adolescents, (2) delineate the determinants and processes that increase vulnerability to or, conversely, protect from the initiation of psychoactive substance use and progression to substance use disorder (SUD) and based on this understanding, (3) develop effective strategies to prevent the initiation and progression of psychoactive substance use.The challenge we now face is incorporating what we have learned from this research into the mindsets and work of those involved in supporting, planning and delivering prevention programming to populations around the world and integrating these scientific advances into existing service systems and, where applicable, within everyday life, i.e., to normalize them.Dissemination and implementation science provides a framework for this solid prevention research to fully achieve its potential.