2019
DOI: 10.1111/jdi.13165
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Commentary on the effects of receptor activator of nuclear factor‐B ligand inhibition on bone mass and muscle strength

Abstract: The pathophysiology of osteoporosis and sarcopenia.

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Cited by 1 publication
(2 citation statements)
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“…To investigate the potential effect of KYMASIN UP in OC formation and function, we induced differentiation of RAW 264.7 cells into OCs by treatment with RANKL (100 ng/mL) [ 14 , 15 ], which is the principal cytokine involved in the osteoclastic differentiation and activation during physiological bone remodeling [ 3 , 5 , 6 , 18 ], for 5 days in the absence or presence of the product. Firstly, different doses of KYMASIN UP (12.5–400 µg/mL) were added to RANKL-treated cultures to evaluate RAW 264.7 cell viability by MTT assay.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…To investigate the potential effect of KYMASIN UP in OC formation and function, we induced differentiation of RAW 264.7 cells into OCs by treatment with RANKL (100 ng/mL) [ 14 , 15 ], which is the principal cytokine involved in the osteoclastic differentiation and activation during physiological bone remodeling [ 3 , 5 , 6 , 18 ], for 5 days in the absence or presence of the product. Firstly, different doses of KYMASIN UP (12.5–400 µg/mL) were added to RANKL-treated cultures to evaluate RAW 264.7 cell viability by MTT assay.…”
Section: Resultsmentioning
confidence: 99%
“…RANKL activity is inhibited by OPG (osteoprotegerin), a member of the TNF receptor superfamily, produced by numerous cell types, including OBs and bone marrow stromal cells [ 3 , 5 , 6 , 18 ]. OPG is a soluble decoy receptor for RANKL preventing its binding to receptor RANK and reducing the differentiation of OCs [ 29 ].…”
Section: Resultsmentioning
confidence: 99%