Commentary on Therapeutic Potential of Gnidia glauca: A Novel Medicinal Plant

Ghosh, Sougata; Parihar, Vijay Singh; Dhavale, Dilip D.; Chopade, Balu A.

doi:10.4172/2161-0444.1000285

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Medicinal plants are considered as store houses of diverse groups of phytochemicals which can be efficiently exploited for therapeutic purposes, chemical reactions and more recently in nanobiotechnology [25][26][27][28][29][30][31]. POLE exhibited excellent potential to reduce Au 3+ and Ag + ions to Au and Ag within 5 h which was found to be effective compared to earlier reports with Sesuvium portulacastrum L that take 24 hours for complete synthesis of AgNPs [32].…”

Section: Discussionmentioning

confidence: 88%

Platanus orientalis Leaf Mediated Rapid Synthesis of Catalytic Gold and Silver Nanoparticles

Shende¹,

Joshi²,

Kulkarni³

et al. 2018

J Nanomed Nanotechnol

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This report details on synthesis of AuNPs and AgNPs using POLE with optimized reaction parameters, for the first time. The bioreduced nanoparticles were characterized using UV-visible spectroscopy, high resolution transmission electron microscopy (HRTEM), energy dispersive spectroscopy (EDS), dynamic light scattering (DLS), X-ray diffraction spectroscopy (XRD), fourier transform infrared (FTIR) spectrometry. Both AuNPs and AgNPs Further we evaluated the catalytic potential of the nanoparticles towards reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) using NaBH 4 . AbstractIn an attempt to synthesize novel catalytic gold (AuNPs) and silver nanoparticles (AgNPs) we have used Platanus orientalis leaf extract for both reduction and capping. The synthesis was rapid which completed by 5 h as indicated by change in colour and development of prominent peak at 540 nm for AuNPs and 440 nm for AgNPs, as revealed by UV-visible spectroscopy. The phytogenic nanoparticles showed exotic shapes which included triangles, spheres, hexagons and pentagons as analyzed by high resolution transmission electron microscopy. The optimized processing parameters like salt concentration (1 mM concentration of HAuCl 4 and 4 mM of AgNO 3 ) and the reaction temperature (50°C) led to faster nanoparticles synthesis. Energy dispersive spectra and X-ray diffraction studies confirmed the elemental gold and silver in AuNPs and AgNPs. Detailed phytochemical characterization using biochemical techniques and gas chromatography mass spectrometry indicated the predominance of ascorbic acid, citric acid, reducing sugars and even starch which may together lead to simultaneous synthesis and capping. Further, AuNPs and AgNPs catalyzed the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) using NaBH 4 with apparent rate constants of 1.908 × 10 -4 min -1 and 3.071 × 10 -4 min -1 , respectively. Figure 1: UV-vis spectra recorded as a function of reaction time for nanoparticle synthesis using POLE at 40°C with (A) HAuCl 4 solution and (B) 1mM AgNO 3 solution.Figure 2: Time course of nanoparticle synthesis using POLE at different reaction temperatures with (A) 1 mM HAuCl 4 and (B) 1 mM AgNO 3 .Figure 10: UV-vis absorption spectra during the reduction of 4-nitrophenol as a function of chemocatalytic activity of (A) AuNPs and (B) AgNPs synthesized by POLE. Inset figures represent plot of ln (A t /A 0 ) versus time for the reduction of 4-NP.

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Section: Discussionmentioning

confidence: 88%

Platanus orientalis Leaf Mediated Rapid Synthesis of Catalytic Gold and Silver Nanoparticles

Shende¹,

Joshi²,

Kulkarni³

et al. 2018

J Nanomed Nanotechnol

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“…In our present study, synthesis of CuNPs was found to be rapid and efficient which is well in agreement with our previous reports where AuNPs and AgNPs were synthesized using the aforementioned plants. The parts of the plants used in this study are reported to contain coumarins like seselin, 5-methoxyseselin, suberosin, xanthyletin, and xanthoxyletin apart from alkaloids, glycoside, reducing sugars, simple phenolics, tannins, lignin, saponins, and flavonoids which have a high potential to synthesize and stabilize nanoparticles [16, 17, 19]. Absorption bands of CuNPs are in the range between 550 and 600 nm.…”

Section: Discussionmentioning

confidence: 99%

“…Gnidia glauca is also known to be of utmost medicinal importance as it is used for treatment of cancers, burns, wounds, abdominal pain, snake bites, and sore throat. Similarly, leaves are applied to treat back ache, joint aches, contusions, and swellings [16, 17]. Another medicinal plant, Plumbago zeylanica , has exhibited carminative, anthelmintic, anti-inflammatory, antiplasmodial, antimicrobial, antifungal, antihyperglycemic, hypolipidaemic, and antiatherosclerotic activities [18].…”

Section: Introductionmentioning

confidence: 99%

Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents

Jamdade

Rajpali

Joshi

et al. 2019

Advances in Pharmacological Sciences

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Rapid, eco-friendly, and cost-effective one-pot synthesis of copper nanoparticles is reported here using medicinal plants like Gnidia glauca and Plumbago zeylanica. Aqueous extracts of flower, leaf, and stem of G. glauca and leaves of P. zeylanica were prepared which could effectively reduce Cu2+ ions to CuNPs within 5 h at 100°C which were further characterized using UV-visible spectroscopy, field emission scanning electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy, dynamic light scattering, X-ray diffraction, and Fourier-transform infrared spectroscopy. Further, the CuNPs were checked for antidiabetic activity using porcine pancreatic α-amylase and α-glucosidase inhibition followed by evaluation of mechanism using circular dichroism spectroscopy. CuNPs were found to be predominantly spherical in nature with a diameter ranging from 1 to 5 nm. The phenolics and flavonoids in the extracts might play a critical role in the synthesis and stabilization process. Significant change in the peak at ∼1095 cm−1 corresponding to C-O-C bond in ether was observed. CuNPs could inhibit porcine pancreatic α-amylase up to 30% to 50%, while they exhibited a more significant inhibition of α-glucosidase from 70% to 88%. The mechanism of enzyme inhibition was attributed due to the conformational change owing to drastic alteration of secondary structure by CuNPs. This is the first study of its kind that provides a strong scientific rationale that phytogenic CuNPs synthesized using G. glauca and P. zeylanica can be considered to develop candidate antidiabetic nanomedicine.

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“…In spite of being safe, cost-effective, sustainable and eco-friendly, microbial synthesis has potential drawbacks like maintenance of sterile conditions, cell mass and size control. Hereby, medicinal plants are considered as efficient sources of photochemical that would not only reduce but also stabilize the bioreduced nanoparticles [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Novel Anticancer Platinum and Palladium Nanoparticles from Barleria prionitis

Ghosh¹

2017

GJN

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Nanomedicines are emerging outcomes of nanobiotechnology which have promising pharmaceutical applications. Although there are various physical and chemical methods for synthesis of nanoparticles, most of them involve hazardous and toxic chemicals. Thus, there is a continuously growing need for investigation of novel routes to synthesize nanoparticles with enhanced biocompatibility and reduced toxicity. Medicinal plants are rich source of diverse photochemical responsible for simultaneous reduction and stabilization of nanoparticles. Herein, we report for the first time, the synthesis of platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using Barleria prionitis leaf extract (BPLE). PtNPs and PdNPs were characterized using UV-visible spectroscopy.High resolution transmission electron microscopy (HRTEM) revealed that the PtNPs were between 1 to 2 nm while PdNPs were between 5 to 7 nm. Further energy dispersive spectroscopy (EDS) and dynamic light scattering (DLS) confirmed the elemental composition and hydrodynamic size, respectively. Fourier transformed infrared spectra (FTIR) confirmed the involvement of diverse photochemical in reduction and stabilization of the nanoparticles. Both PtNPs and PdNPs were tested for anticancer activity against human breast adenocarcinoma (MCF-7) cell lines which showed reduced viability up to 60.08 ± 2.4 % and 57.22 ± 1.68 %, respectively. Further, flow cytometric studies and confocal microscopy using dual staining method with annexin V-FITC and propidium iodide indicated apoptosis induction as the plausible mechanism exhibiting externalization of phosphatidylserine and loss of cell membrane integrity. This is the first report on PtNPs and PdNPs synthesized by BPLE as promising anticancer agents.

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Commentary on Therapeutic Potential of Gnidia glauca: A Novel Medicinal Plant

Cited by 6 publications

References 8 publications

Platanus orientalis Leaf Mediated Rapid Synthesis of Catalytic Gold and Silver Nanoparticles

Platanus orientalis Leaf Mediated Rapid Synthesis of Catalytic Gold and Silver Nanoparticles

Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents

Novel Anticancer Platinum and Palladium Nanoparticles from Barleria prionitis

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