Commentary re: Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy

Simpson, Joe Leigh; Kuliev, Anver

doi:10.1016/j.rbmo.2016.08.018

Cited by 2 publications

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“…If a couple lacks non-mosaic euploid embryos, one might thus perform transfer of a mosaic aneuploid embryo with patient consent. The need for clarity is recognized by Commentaries [99,[103][104][105].…”

Section: Pgt-aneuploidy (Pgt-a) To Improve Pregnancy Ratesmentioning

confidence: 99%

Overview of Preimplantation Genetic Diagnosis (PGD): Historical Perspective and Future Direction

Simpson

Kuliev

Rechitsky

2018

Methods in Molecular Biology

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Preimplantation genetic diagnosis (PGD) can be considered the earliest form of prenatal testing. It was first used in humans over 26 years ago. At its inception, PGD could only be performed for a limited number of genetic disorders. Technological advances in molecular biology and cytogenomics have been utilized in the field of PGD to greatly expand the spectrum of genetic disorders that can now be detected in early human embryos.

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Section: Pgt-aneuploidy (Pgt-a) To Improve Pregnancy Ratesmentioning

confidence: 99%

Overview of Preimplantation Genetic Diagnosis (PGD): Historical Perspective and Future Direction

Simpson

Kuliev

Rechitsky

2018

Methods in Molecular Biology

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Preimplantation genetic testing: current challenges and future prospects

Kuliev

Rechitsky

2017

Expert Review of Molecular Diagnostics

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Preimplantation genetic testing (PGT) is now a widely applied procedure in genetic practices and ART, with more than one third of ART Centers in US already utilizing PGT technology. Its indications have also been significantly extended to include common late-onset disorders and non-genetic conditions, such as testing for HLA match. Areas covered: This is a critical review of the developments in PGT, with emphasis on their outstanding limitations and directions for the future research and practice in the area of PGT. Expert commentary: The application of the new higher resolution PGT technologies has led to the identification of genetic variations, the biological and clinical importance of which is not sufficiently understood. It is obvious that the current selection process of embryos with the highest developmental potential requires a further improvement, as significant proportion of transferred euploid embryos still fail to result in an ongoing clinical pregnancy. More research will be needed to upgrade PGT for different conditions into a single universal test in the same biopsy material. To avoid a potential damage of embryo biopsy procedures, one of the important challenges will be the development of non-invasive approaches to PGT.

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Commentary re: Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy

Cited by 2 publications

References 1 publication

Overview of Preimplantation Genetic Diagnosis (PGD): Historical Perspective and Future Direction

Overview of Preimplantation Genetic Diagnosis (PGD): Historical Perspective and Future Direction

Preimplantation genetic testing: current challenges and future prospects

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