The times they are a-changin': paradigm shifts in child and adolescent psychology and psychiatryThe world is a different place than it was more than 2 years ago, at the start of the COVID-19 pandemic.The times are always changing, but events of the recent past have radically shifted how we work, when and how we interact with each other, and how we understand our history. The papers in the current issue echo this spirit of change, challenging us to fundamentally re-think how we conceptualize psychopathology, where we define boundaries between 'normal' and 'abnormal' (and, who gets to define those boundaries), and whether our current conceptual models are generalizable to ever more diverse groups. These challenges represent healthy and timely critiques of dominant paradigms. Collectively, the authors who contributed to the current Annual Research Review make the case that these new frameworks will have big pay-offs in terms of improving clinical practice and policy.What are these new frameworks? Several of the papers included in the 2022 Annual Research Review demonstrate how influential the Research Domain Criteria (RDoC) framework has been in shaping the kinds of questions researchers ask and the methods they use to answer them. As described by Pacheco et al., (2022), the National Institute of Mental Health (NIMH) launched the RDoC initiative in 2009 to overcome many of the limitations of the clinical model, wherein psychiatric diagnoses were defined in terms of observable symptoms that were not, ultimately, closely related to psychological or neural mechanisms. The RDoC initiative identified domains of cognition and behavior that cut across diagnoses and could be studied at the genetic, neural, cognitive, or behavioral level, with the idea being that researchers wouldideallydemonstrate connections across multiple units of analysis. NIMH incentivized researchers to adopt the RDoC approach by offering RDoC-specific funding opportunities and integrating RDoC goals into their Strategic Plan.Ten years on, how has RDoC changed the kind of science that psychopathology researchers do? The answer to this question is clear, not only from the data Pacheco and colleagues provide from a review of