Commentary: Regional variations in oesophageal and gastric cardia cancers—implications and practice

Eksteen, J A; Latchford, Andrew; Thomas, Sapna; Jankowski, Janusz

doi:10.1093/ije/30.6.1425

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Male female ratio in of the cause suggested that two factors are of importance. For decades Barrets oesophagus, a complication of reflux eosophagitis, has been regarded as having unquantified maliganant potential and a recent Swedish study showed a strong link between reflux and adenocarcinomas of gastric cardia and lower 14,15 oesophagus . In view of the association between obesity and reflux and cancer of lower oesophagus and cardia, there is no strong links.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of gastric cancer in jos university teaching hospital jos a 20 year review of cases

Mandong¹,

Manasseh²,

Tanko³

et al. 2010

Nig. J. Med.

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Background: Gastric cancer believed to be rare in the past in Africa, is now one of the leading cancer morbidity and mortality. It is now known gastric cancer is 2-3 times higher in males than females living in the same environment. We aim to describe the comprehensive histological characteristics of gastric cancer with age and sex distribution. Methods: The study site was Jos University Teaching Hospital situated in the capital of Plateau State. The hospital has a bed capacity of 530. The study materials were obtained from all stained specimens of gastric cancer recorded in the histopathology laboratory of the teaching hospital between 1985 to 2004. The biopsy site was noted. These were divided into the following groups: Cardia, body and an thrum/pyloric regions respectively. Or the information included age and sex of the patients. Results: There were a total of 205 gastric cancer histological confirmed, out of 5705 malignant tumours recorded in the same period. There were a total of 145 cases in male and 60 in females giving a male: female ratio 2.4:1. The highest frequencies of gastric cancers were located in the anthral and cardia regions which accounted for 79% of all the tumours. Well differentiated adenocarcinoma (intestinal type) was the most frequent histological subtypes 51.2%), this was followed by poorly and diffusely infiltrating carcinoma. Other cancers included signet ring carcinoma, Non-Hodgkin's lymphoma and leiomyosarcoma in that order. The study has also demonstrated H pylori at the background of intestinal type adenocarcinoma which was seen in the body and an thrum. Conclusion:The study has shown that gastric cancer is not only common but it occur more males than females. The high proportion of H pylori in our environment might indicate a possible aetiological association. Therefore eradication of H pylori might reduce the prevalence of gastric carcinoma.

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Section: Discussionmentioning

confidence: 99%

“…The carcinogenic factor of hydrocarbon in grilled or smoked meat or fish had been suggested as a possible factor. Grilled meat is however, probably more widely consumed in USA in any other country in the world, but [13][14][15] it has been a declining incidence of gastric cancer .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of gastric cancer in jos university teaching hospital jos a 20 year review of cases

Mandong¹,

Manasseh²,

Tanko³

et al. 2010

Nig. J. Med.

View full text Add to dashboard Cite

show abstract

“…In Scotland, where the highest cumulative rates of oesophageal adenocarcinomas in the world have been reported [3], high rates are observed in both sexes. High intake of saturated fats and high rates of obesity and cigarette smoking have been proposed as factors that could be implicated in these findings [41]. …”

Section: Discussionmentioning

confidence: 99%