Commentary: Squamous Cell Carcinoma of the Tongue in Young Patients: A Case Series and Literature Review

Carr, Brian R.; Gulko, J.A.; Neal, Timothy W.; Schlieve, Thomas

doi:10.1016/j.joms.2021.08.272

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TSCC, as a tumor with an extremely high incidence in the oral and maxillofacial region, has a 5-year survival rate of less than 50%, although with the continuous improvement of surgery as well as comprehensive treatments such as radiotherapy and chemotherapy (Carr et al 2021). Among them, the significant biological predisposition to local invasion and the high incidence of early cervical lymph node metastasis are important factors contributing to the poor prognosis of patients with TSCC (Wang et al 2021a).…”

Section: Discussionmentioning

confidence: 99%

Rhaponticin suppresses the hypoxia-induced factor-1 alpha-mediated aggressive phenotype of tongue squamous cell carcinoma

Wan

Shao

et al. 2023

Mol. Cell. Toxicol.

View full text Add to dashboard Cite

Background Emerging evidence suggests that rhaponticin, a stilbene monomeric compound isolated from North China rhubarb, has been shown to exhibit significant biological activity against tumors. However, the anticancer effects and mechanisms of rhaponticin in tongue squamous cell carcinoma (TSCC) remain elusive. Objective We investigated the changes of migration and invasion abilities and EMT progression of TSCC cells treated with different concentrations of rhaponticin under hypoxia, as well as the possible mechanisms, in order to initially explore the effects of rhaponticin on the biological characteristics of TSCC cells under hypoxia. Results The number of cell migration and invasion was prominently increased, E-cadherin protein was down-regulated, and N-cadherin and HIF-1α protein expression was elevated under hypoxia. Rhaponticin intervention strikingly prevented the increased abilities of migration and invasion and EMT of TSCC cells under hypoxia. This was followed by further validation finding that rhaponticin indeed leads to reduced HIF-1α post-transcriptional activity. Mechanistically, rhaponticin may bind to aryl-hydrocarbon nuclear translocator (ARNT) domain of HIF-1α. Conclusions Rhaponticin repressed the invasion and migration abilities and EMT process of TSCC cells under a hypoxic environment in vitro by targeted suppression of HIF-1α.

show abstract

Section: Discussionmentioning

confidence: 99%