Commentary: The spectrum of neurological manifestations related to COVID-19 and vaccinations

Samudralwar, Rohini

doi:10.1016/j.jneuroim.2021.577660

Cited by 3 publications

(4 citation statements)

References 11 publications

(14 reference statements)

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“…2 Most reported adverse effects following COVID-19 vaccination have been systemic, local, or allergic reactions. 1 Although rare, there is still concern over neurological vaccine-related side effects 10 ; however, only two patients to date have reportedly developed NA involving the brachial plexus after receiving the BNT-162b2 (Pfizer, New York, NY, USA) vaccination antigen. 6,9 The vaccination is suspected to elicit an immune-mediated inflammatory response to the injected antigen, 6,9 and this vaccine-triggered immune reaction may result in an NA attack involving the lumbosacral plexus.…”

Section: Discussionmentioning

confidence: 99%

Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report

Kim

Seok

et al. 2021

J Int Med Res

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The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after AstraZeneca COVID-19 vaccination. The patient presented with acute-onset leg paralysis following administration of the vaccine. Based on the clinical, electrodiagnostic, and radiologic findings, the patient was diagnosed with post-vaccination NA. We speculate that the COVID-19 vaccine elicited an immune-mediated inflammatory response to the injected antigen due to inflammatory immunity in a patient with predisposed susceptibility to NA.

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Section: Discussionmentioning

confidence: 99%

Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report

Kim

Seok

et al. 2021

J Int Med Res

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“…Other patterns including LETM associated with mild encephalitis/encephalopathy with a reversible splenial lesion have been reported although, in most cases, establishment of possible causation in lieu of association is challenging ( Kim et al, 2021 ). Therefore, there is still a need for establishing SARS-CoV-2 specific neurologic manifestations, their long-term prognosis, and to define probable or definite causation ( Ellul et al, 2020 ; Samudralwar, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…possible causation in lieu of association is challenging (Kim et al, 2021). Therefore, there is still a need for establishing SARS-CoV-2 specific neurologic manifestations, their long-term prognosis, and to define probable or definite causation (Ellul et al, 2020;Samudralwar, 2021).…”

Section: Discussionmentioning

confidence: 99%

Longitudinally extensive transverse myelitis with anti-myelin oligodendrocyte glycoprotein antibodies following SARS-CoV-2 infection

Costa

Rato

Cruz

et al. 2021

Journal of Neuroimmunology

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We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients.

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“…Uno de los sistemas afectados por esta autoinmunidad es el sistema nervioso, que conlleva al desarrollo del síndrome de Guillain-Barré (SGB) (3,4) . Se postula que el daño en la vaina de mielina se deba, posiblemente, a la producción de anticuerpos inducida por la COVID-19, apoyándose en la adecuada respuesta al tratamiento (77,6%) con inmunoglobulina intravenosa (IG-IV) (3,4) . Sin embargo, es poco lo que se conoce acerca de la púrpura trombocitopénica inmune (PTI) secundaria a la COVID-19 (PTI-COVID-19) (5) .…”

Section: Introductionunclassified

Concurrencia entre el síndrome de Guillain-Barré y púrpura trombocitopénica inmune posiblemente inducidos por COVID-19 prolongado

Pichardo-Rodriguez

Hernández

Ramírez-Meyhuay

et al. 2022

Rev Peru Med Exp Salud Publica

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Durante la infección aguda por el SARVS-CoV-2 se produce una desregulación del sistema inmune que puede durar hasta ocho meses después de controlado el cuadro agudo. Esto, sumado a otros factores, posiblemente este asociado con un aumento del riesgo de aparición y concurrencia de enfermedades autoinmunes. La aparición simultanea del síndrome de Guillain-Barré (SGB) y púrpura trombocitopénica (PTI) se ha reportado poco en la literatura, y el SGB raramente se asocia con otra enfermedad autoinmune. Presentamos el caso de un varón que luego de un mes de tener un cuadro agudo de COVID-19 moderado, presentó concurrentemente SGB y PTI con respuesta adecuada al tratamiento.

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Commentary: The spectrum of neurological manifestations related to COVID-19 and vaccinations

Cited by 3 publications

References 11 publications

Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report

Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report

Longitudinally extensive transverse myelitis with anti-myelin oligodendrocyte glycoprotein antibodies following SARS-CoV-2 infection

Concurrencia entre el síndrome de Guillain-Barré y púrpura trombocitopénica inmune posiblemente inducidos por COVID-19 prolongado

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