Commentary: What is the relationship between Covid-19 and cardiovascular disease?

Ferrari, Roberto; Pasquale, G. Di; Rapezzi, Claudio

doi:10.1016/j.ijcard.2020.03.074

Cited by 32 publications

(28 citation statements)

References 10 publications

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“…Similar to many studies, presence of diabetes and CAD in patients in the current study were signi cantly associated with requiring critical care [14,15]. A meta-analysis study from China (n = 1527 patients)…”

Section: Discussionsupporting

confidence: 81%

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Clinical characteristics of confirmed cases of COVID-19 admitted at Al-Nahdha hospital, Oman: a cross-sectional descriptive study

Harthi

AlOsali

Ismaili

et al. 2020

Preprint

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Abstract Background: With the coronavirus disease 19 (COVID-19) pervading the world, little has been published regarding the hospitalized cases of COVID-19 (confirmed) in the Arabian Gulf countries. This paper describes the socio-demographic, clinical, laboratory, and radiological characteristics, treatment and clinical outcomes of these cases in Al-Nahdha hospital, Oman. Additionally, factors associated with requiring critical care were identified.Methods: Data of all the positive cases in Al-Nahdha hospital were retrieved from the electronic health information system retrospectively from 3rd of March to 9th May 2020. Required information was recorded in a bespoke sheet and exported to SPSS for further analysis. The primary outcome was defined as requiring vs not requiring critical care.Results:Out of 102 total admissions, 19 cases required critical care (18.6%). Compared to the non-critical cases, majority of the severe cases requiring critical care were older [54.1(13.4) years vs 48.9(14.9) years], males [89.5% vs 74.7%] and non-nationals [63.2 vs 55.4%]. Significant factors associated with requiring critical care were symptoms of shortness of breath (89.5% vs 65.1%, P=0.03), diabetes (68.4% vs 32.5%, OR=1.5, P=0.004), chronic artery disease (15.8% vs 3.6%, OR=1.7, P=0.04), diagnosis of ARDS (63.2% vs 6.0%, P<0.001). Additionally, the mean ferritin levels was significantly higher in cases requiring critical care compared to their counter cases (2350.4(423.8) vs 795.7(554.3), P=0.005). Depending on disease severity, treatment included anti-bacterial, anti-viral, heparin and steroids. The utilization of steroids was significantly higher in the cases requiring critical care (63.2% vs 26.5%, P=0.001). Out of cases who required critical care (n=19), nine died (death rate= 47.4%). Conclusions:Results from this study provides fundamental information about the non-clinical and clinical characteristics of confirmed COVID-19 cases in Oman. The information obtained can be utilized to follow up the clinical progress of hospitalized patients with COVID-19 in the Arabic speaking countries where such reports are limited.

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Section: Discussionsupporting

confidence: 81%

“…Unlike others studies, asthma and other comorbidities in the current study were not signi cantly associated with requiring critical care [14,15]. Future studies may consider larger sample size to unfold any associations.…”

Section: Discussioncontrasting

confidence: 71%

Clinical characteristics of confirmed cases of COVID-19 admitted at Al-Nahdha hospital, Oman: a cross-sectional descriptive study

Harthi

AlOsali

Ismaili

et al. 2020

Preprint

View full text Add to dashboard Cite

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“… ( Rizzo et al, 2020 ) Review Understanding COVID-19 patients and cardiovascular disease interaction for management Existing understanding between cardiovascular disease and COVID-19 is insufficient and much needed for future research. ( Bansal, 2020 ) Commentary Cardiologist and treatment in COVID-19 The impact of cardiovascular drugs on COVID19 patients remain uncertain ( Ferrari et al, 2020 ) Research article COVID-19 and cardiovascular morbidity and mortality COVID-19 patients are at elevated risk for morbidity and mortality in patients with cardiovascular comorbidity. ( Clerkin et al, 2020 ) Comment COVID-19 causes acute damage to the myocardium and chronically to the cardiovascular system Special attention to the diagnosis and care of COVID-19 heart disease patients ( Zheng et al, 2020 ) Review COVID-19 and special emphasis on the cardiovascular system COVID-19 induces myocarditis, arrhtymias and extremely likned to hyperinflammation ( Madjid et al, 2020 ) Summary Pandemic COVID-19 cardiovascular risk in individuals who are infected & not infected.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes

Loganathan

Maheshkumar

Wankhar

et al. 2021

Respiratory Physiology & Neurobiology

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“…However, it remains unclear whether acute cardiac involvement is primarily provoked by SARS-CoV-2 or whether it is a multifactorial non-specific cardiac involvement of a severe systemic infection. 13 It has been proposed that SARS-CoV-2 may lead to cardiac injury via multiple mechanisms including direct viral invasion of cardiomyocytes and subsequent myocarditis, since viral particles have been identified in myocardial cells. 14 However, changes in cTnI over time and the absence of typical signs on echocardiography and ECG in patients with COVID-19 have suggested that myocardial injury in patients with COVID-19 is more likely related to systemic consequences of disease.…”

Section: Discussionmentioning

confidence: 99%

Biomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19

Martins-Filho¹,

Barreto-Filho²,

Santos³

2020

Arquivos Brasileiros De Cardiologia

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Background: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19. Methods: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results. Results: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-Btype natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection. Conclusions: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277

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Commentary: What is the relationship between Covid-19 and cardiovascular disease?

Cited by 32 publications

References 10 publications

Clinical characteristics of confirmed cases of COVID-19 admitted at Al-Nahdha hospital, Oman: a cross-sectional descriptive study

Clinical characteristics of confirmed cases of COVID-19 admitted at Al-Nahdha hospital, Oman: a cross-sectional descriptive study

Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes

Biomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19

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