Comments on Evaluation of Endoscopic Findings and Detection of &lt;i&gt;H. pylori&lt;/i&gt; Antibody by Serum IgG ELISA

Islam, Mdu; Rahman, Shz; Shamsuzzaman, SM; Muazzam, Naima; Chowdhury, A. K.; Ar, Sarkar

doi:10.3329/fmcj.v6i1.7406

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…Among findings 12.7% had PUD, 3% gastric ulcer, 7% gastritis, 5.3% gastric tumor, 14.7% oesophageal varices, 5% reflux oesophagitis, 2.3% oesophageal carcinoma and 3% others (Table-V). This study finding is more or less similar with other findings revealed by endoscopy in Bangladesh 16 where gastroduodenal mucosa was found normal in 58.14%, gastritis in 11.63%, duodenitis 2.33%, reflux oesophagitis 4.65%, peptic ulcer 17.44% and carcinoma of stomach 5.81%. In another study in Bangladesh, endoscopy revealed that duodenal ulcer 34% was the most common cause of UGI bleeding followed by rupture of portal varices 16%, neoplasm 10%, gastric ulcer 08% and gastric erosion 06% 8 .…”

Section: Resultssupporting

confidence: 90%

Appropriateness of Referral for Upper Gastrointestinal Endoscopy in a Tertiary Care Hospital

Khan¹,

Wahab

Yasin³

et al. 2020

J. Armed Forces Med. Coll.

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Introduction: Upper gastrointestinal endoscopy (UGE) allows physicians to directly schedule endoscopic procedures for their patients without prior consultation. Evaluation of appropriateness of endoscopic procedures is associated with costs and beneﬁts. Objectives: To assess the appropriateness of the use of UGE in an open-access setting in Bangladesh. Materials and Methods: This cross-sectional multicenter study was conducted among 300 patients referred for UGE at Dhaka Medical College Hospital and Shaheed Suhrawardi Medical College and Hospital from January 2016 to June 2016. The American Society for Gastrointestinal Endoscopy (ASGE) guidelines was used to assess the appropriateness of referral. The participants were selected by purposive nonprobability sampling and a pre-tested questionnaire was used for data collection. Results: Out of 300 respondents 62.3% was male. History of smoking was more in male and taking NSAIDs were more in the female. In UGE 46.7% revealed normal findings but majority 53.3% had some pathology. About 86% cases, UGE was found appropriate according to ASGE guideline and majority appropriate cases 37.3% were referred by internal medicine specialist. Appropriateness of referral among different physicians was not statistically significant. Conclusion: Appropriateness of referral for UGE performed in tertiary care level hospitals in an open-access setting like Bangladesh was satisfactory. Journal of Armed Forces Medical College Bangladesh Vol.14 (2) 2018: 152-155

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Section: Resultssupporting

confidence: 90%

Appropriateness of Referral for Upper Gastrointestinal Endoscopy in a Tertiary Care Hospital

Khan¹,

Wahab

Yasin³

et al. 2020

J. Armed Forces Med. Coll.

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“…Patients presented with the symptoms of dyspepsia for more than 1 month were included in this study. 27 Individuals having severe medical or surgical illness such as asthma, COPD, previous gastric surgery etc and history of intake of proton pump inhibitors, non-steroidal anti-inflammatory drugs, colloidal bismuth compounds, or antibiotics for eradication of H. Pylori over the past four weeks of enrolment were excluded from this study. 28 After taking written informed consent from each patient, four endoscopic gastric biopsy tissue were collected from lesion and surrounding sites in gastric antrum and body.…”

Section: Sample Collection and Processingmentioning

confidence: 99%

Mutational Analysis of Clarithromycin and Levofloxacin Resistance in Helicobacter pylori from Gastric Biopsy Specimens in a Tertiary Care Hospital in Dhaka, Bangladesh

Tanni

Anwar

Ahmed

et al. 2019

Bangladesh J Med Microbiol

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Background: Clarithromycin and Levofloxacin are most frequently included in the standard triple therapies for H. pylori eradication in our country. Resistance to clarithromycin and fluoroquinolones are particularly related with treatment failure. Objectives: The objective of this study was to detect, clarithromycin and levofloxacin resistance associated with gene mutations in H. pylori directly from gastric biopsies using an allele specific primer-PCR (ASP-PCR) assay. Materials and Methods: Gastric biopsy specimens were collected from 143 adult dyspeptic patients, from Department of Gastroenterology, BSMMU and Dhaka Medical College Hospital (DMCH), during the period of March, 2018 to February, 2019. H. pylori was identified by rapid urease test, ureC gene by PCR, histological staining and culture. ASP-PCR was used to identify 23S rRNA gene and gyrA gene mutation predictive of clarithromycin and levofloxacin resistant H. pylori respectively. Results: H. pylori positive cases were 32.9% based on the case definition used in the study. Among 42 ureC positive H. pylori cases, point mutations in 23Sr RNA gene for clarithromycin resistance were detected only at A2142G position in 9 (21.4%) cases and gyrA gene mutations for levofloxacin resistance were detected in 16 (38.1%) cases. Only 1 (2.4%) case had mutation both in 23Sr RNA and gyrA gene. Conclusion: Those findings may guide toward the therapeutic choices in our country. PCR based diagnostic assays can be the alternative approach for rapid detection of antibiotic resistances of H. pylori directly from gastric biopsies, where culture and susceptibility tests are not routinely performed. Bangladesh J Med Microbiol 2019; 13 (1): 12-19

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“… 5 Individuals already receiving triple therapy for H. pylori eradication, therapy in the previous 2 months, had taken anti-ulcerant drugs including proton pump inhibitors (PPI), painkillers such as nonsteroidal anti-inflammatory drugs (NSAID), or any antibiotic 1 month before enrollment were ultimately excluded from this study. 7 - 9 …”

Section: Methodsmentioning

confidence: 99%

Diagnosis and Comparison of Three Invasive Detection Methods for Helicobacter pylori Infection

et al. 2022

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Background: The purpose of this study was to compare different invasive methods for Helicobacter pylori ( H. pylori) detection, namely PCR for H. pylori specific ureC gene, Rapid urease test (RUT), and histopathological examination by modified Giemsa staining. Methodology: Endoscopic gastroduodenal biopsy materials were collected from dyspeptic patients who underwent endoscopic examination upon fulfilling the inclusion criteria. Three to four samples were collected from each patient after taking informed consent and proper clinical history. A rapid urease test (RUT) was done on spot with in-house RUT media from 1 specimen. One to two specimens were preserved in 10% formaldehyde for histopathology and PCR for ureC gene was done from 1 specimen. Collected biopsy specimens from gastric and duodenal mucosa of 142 patients were categorized as H. pylori-positive cases and H. pylori-negative cases based on the case definition used in the study upon positivity of 3 diagnostic tests. Results: Among 142 biopsy specimens, 34.5% were categorized as H. pylori-positive cases, 35.2% as H. pylori-negative cases, and finally 30.2% as doubtful or indeterminate cases. Rapid urease test was the most sensitive method, closely followed by ureC gene PCR and histopathology, with a sensitivity of 94.2%, 83.0%, and 76.5%, respectively. Whereas histology was the most specific, having 98.0% specificity followed by 83.0% in PCR. RUT was the least specific, with 55.5% specificity. Conclusion: While histopathology could detect H. pylori infection with the highest specificity, for definitive diagnosis combination of any 2 methods should be used, if available.

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Comments on Evaluation of Endoscopic Findings and Detection of <i>H. pylori</i> Antibody by Serum IgG ELISA

Cited by 5 publications

References 13 publications

Appropriateness of Referral for Upper Gastrointestinal Endoscopy in a Tertiary Care Hospital

Appropriateness of Referral for Upper Gastrointestinal Endoscopy in a Tertiary Care Hospital

Mutational Analysis of Clarithromycin and Levofloxacin Resistance in Helicobacter pylori from Gastric Biopsy Specimens in a Tertiary Care Hospital in Dhaka, Bangladesh

Diagnosis and Comparison of Three Invasive Detection Methods for Helicobacter pylori Infection

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