Comments on “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize”

Tien, Dung Le; Huy, Ham Le

doi:10.1016/j.fct.2012.10.054

Cited by 3 publications

(4 citation statements)

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“…One focus area of contention has been the human safety of glyphosate, which has been repeatedly challenged by interest groups via the media, as well as select research publications in the scientific literature ( Antoniou et al 2012 , Aris and Leblanc 2011 , Aris and Paris 2010 , Benachour and Seralini 2009 , Gasnier et al 2010 , Paganelli et al 2010 , Romano et al 2012 , Romano et al 2010 ). To that end, one specific publication by Seralini et al (2012, retracted) drew significant criticism from both the toxicology and broader scientific communities ( Barale-Thomas 2013 , Berry 2013 , de Souza and Oda 2013 , Grunewald and Bury 2013 , Hammond et al 2013 , Langridge 2013 , Le Tien and Le Huy 2013 , Ollivier 2013 , Panchin 2013 , Sanders et al 2013 , Schorsch 2013 , Tester 2013 , Trewavas 2013 , Tribe 2013 ). After a special review of the investigators’ raw data by a mutually agreed-upon expert panel, the manuscript was retracted by Food and Chemical Toxicology (FCT), for reasons of inconclusive data and unreliable conclusions ( Hayes 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies

Greim

Saltmiras

Mostert³

et al. 2015

Critical Reviews in Toxicology

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Glyphosate, an herbicidal derivative of the amino acid glycine, was introduced to agriculture in the 1970s. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants. After almost forty years of commercial use, and multiple regulatory approvals including toxicology evaluations, literature reviews, and numerous human health risk assessments, the clear and consistent conclusions are that glyphosate is of low toxicological concern, and no concerns exist with respect to glyphosate use and cancer in humans. This manuscript discusses the basis for these conclusions. Most toxicological studies informing regulatory evaluations are of commercial interest and are proprietary in nature. Given the widespread attention to this molecule, the authors gained access to carcinogenicity data submitted to regulatory agencies and present overviews of each study, followed by a weight of evidence evaluation of tumor incidence data. Fourteen carcinogenicity studies (nine rat and five mouse) are evaluated for their individual reliability, and select neoplasms are identified for further evaluation across the data base. The original tumor incidence data from study reports are presented in the online data supplement. There was no evidence of a carcinogenic effect related to glyphosate treatment. The lack of a plausible mechanism, along with published epidemiology studies, which fail to demonstrate clear, statistically significant, unbiased and non-confounded associations between glyphosate and cancer of any single etiology, and a compelling weight of evidence, support the conclusion that glyphosate does not present concern with respect to carcinogenic potential in humans.

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Section: Introductionmentioning

confidence: 99%

Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies

Greim

Saltmiras

Mostert³

et al. 2015

Critical Reviews in Toxicology

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“…Numerous critics argued that the sample size (ten per male and female group) was too small to draw meaningful conclusions, especially for long-term studies in which the laboratory animals are likely to develop significant health problems after 18 months (Arjo et al 2013; de Souza and Macedo 2013; Grunewald and Bury 2013; Hammond et al 2013; Robert et al 2013; Tien and Huy 2013). According to several critics, the control group and nine experimental groups should have included at least 50 animals per sex (Grunewald and Bury 2013; Hammond et al 2013; Langridge 2013; Robert et al 2013; Tien and Huy 2013).…”

Section: Criticism Of the Studymentioning

confidence: 99%

“…According to several critics, the control group and nine experimental groups should have included at least 50 animals per sex (Grunewald and Bury 2013; Hammond et al 2013; Langridge 2013; Robert et al 2013; Tien and Huy 2013). …”

Section: Criticism Of the Studymentioning

confidence: 99%

“…According to several critics, Sprague-Dawley rats should not have been used in this experiment, given their tendency to develop health problems by 18 months of age (Arjo et al 2013; de Souza and Macedo 2013; Grunewald and Bury 2013; Tien and Huy 2013). To avoid minimize confounding factors related to the natural deterioration of health the study should have used a rodent with a better long-term track record (Arjo et al 2013).…”

Section: Criticism Of the Studymentioning

confidence: 99%

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Retracting Inconclusive Research: Lessons from the Séralini GM Maize Feeding Study

Resnik

2015

J Agric Environ Ethics

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In September 2012, Gilles-Eric Séralini and seven coauthors published an article in Food and Chemical Toxicology claiming that rats fed Roundup©-resistant genetically modified maize alone, genetically modified maize with Roundup©, or Roundup© for 2 years had a higher percentage of tumors and kidney and liver damage than normal controls. Shortly after this study was published, numerous scientists and several scientific organizations criticized the research as methodologically and ethically flawed. In January 2014, the journal retracted the article without the authors’ consent on the grounds that the research was inconclusive. In June 2014, Environmental Sciences Europe published a slightly modified version of the retracted paper. The publication, retraction and subsequent republication of the Séralini study raise important scientific and ethical issues for journal editors. Decisions to retract an article should be made on the basis of well-established policies. Articles should be retracted only for serious errors that undermine the reliability of the data or results, or for serious ethical lapses, such as research misconduct or mistreatment of animal or human subjects. Inconclusiveness, by itself, is not a sufficient reason for retracting an article, though a flawed study design might be. Retracted articles that are submitted for republication should undergo scientific review to ensure that they meet appropriate standards. Republished articles should be linked to the original, retracted publication. Journals that are reviewing studies with significant scientific and social implications should take special care to ensure that peer review is rigorous and fair.

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Oncofly: A CURE for Cancer

Reed

Couet

2021

Preprint

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Course-based Undergraduate Research Experiences (CURE’s) are emerging as a means to engage large numbers of undergraduate students in meaningful inquiry-based research activities. We describe here a simple laboratory exercise as part of an undergraduate genetics course that illustrates the contributions of oncogenes and tumor suppressors to the formation of neoplasms in an invertebrate model system. In addition, students were challenged to investigate whether flies reared on a diet containing a variety of additives display a higher number of invasive tumors in the larval abdomen.The goal of the exercise was to (i) familiarize students with the multigenic origin of the cancer phenotype, to (ii) introduce some of the fundamental molecular cancer hallmarks, and to (iii) highlight the significance of invertebrate model systems in biomedical research. Furthermore, (iv) students learn to execute a molecular test for transgenic produce and (v) apply statistical tools to test a simple hypothesis.We evaluated student learning and changes in opinions and attitudes relating to environmental versus genetic causes of cancer and several common misconceptions using a questionnaire before and after completing the exercise.Overall, significant improvements in the rate of factually correct responses and reductions in uncertainty were demonstrated. Although resistance to change was apparent in regard to identifying some risk factors, there was clear learning and understanding of the core concepts of carcinogenesis and the utility of basic research with model organisms.

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Comments on “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize”

Cited by 3 publications

References 4 publications

Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies

Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies

Retracting Inconclusive Research: Lessons from the Séralini GM Maize Feeding Study

Oncofly: A CURE for Cancer

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