Comments on “Salivary 8-hydroxy-2-deoxyguanosine, malondialdehyde, vitamin C, and vitamin E in oral pre-cancer and cancer: diagnostic value and free radical mechanism of action”

Khoubnasabjafari, Maryam; Ansarin, Khalil; Vaez-Gharamaleki, Jalil; Jouyban, Abolghasem

doi:10.1007/s00784-015-1687-x

Cited by 5 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In response to comment [1] on our published article [2], we would like to point out that cancer has indeed different pathways involving oxidative stress, hormonal factors, inflammation, and others. As such, cancer is considered a multi pathway disease, involving various diagnostic markers.…”

Section: Dear Editormentioning

confidence: 99%

Response on: Comments on “Salivary 8-hydroxy-2-deoxyguanosine, malondialdehyde, vitamin C, and vitamin E in oral pre-cancer and cancer: diagnostic value and free radical mechanism of action”

2015

View full text Add to dashboard Cite

Dear Editor:In response to comment [1] on our published article [2], we would like to point out that cancer has indeed different pathways involving oxidative stress, hormonal factors, inflammation, and others. As such, cancer is considered a multi pathway disease, involving various diagnostic markers. In this way, salivary biomarkers may be multiple (8-hydroxy-2-deoxyguanosine, malondialdehyde (MDA), vitamin C, and vitamin E) but at the same time also present some further challenges to act as diagnostic biomarkers of oral pre-cancer and cancer.Variations in salivary MDA level are caused by different collection time, different storage time, time from collection to analysis or collection to storage, and analysis methods. In the present study, a standardized method of collection was followed, i.e., drooling method with minimum time for storage and standardized analysis parameters, in order to enable reproducing results. At the same time, and in combination with other biomarkers, salivary MDA as an oxidative biomarker may be considered a reliable biomarker for oral pre-cancer and cancer [3][4][5]. Considering both aforementioned factors, it can be stated that salivary MDA may be a reliable biomarker if standardized methods of collection, storage, and analysis are followed [3][4][5].

show abstract

Section: Dear Editormentioning

confidence: 99%

Response on: Comments on “Salivary 8-hydroxy-2-deoxyguanosine, malondialdehyde, vitamin C, and vitamin E in oral pre-cancer and cancer: diagnostic value and free radical mechanism of action”

2015

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5] Although the results of case-control comparisons using statistical analyses showed significant increase in the case groups, however there are some non-significant changes and also some significant decreased values for MDA of case groups against control groups. [6][7][8][9][10] In addition there are very wide variations in the reported MDA values in both case and/or healthy control groups. The variations are wider when various analytical methods are considered 6 .…”

Section: Introductionmentioning

confidence: 99%