Comments on the 2014 Helsinki Consensus Report on Asbestos

Landrigan, Philip J.; Ramazzini, Collegium

doi:10.1016/j.aogh.2016.01.018

Cited by 11 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the mechanism of the diseases is still not completely elucidated, causality for silica, asbestos and coal dust is demonstrated by post mortem pathohistological evaluation of lung tissue for silicosis, asbestosis and coalworker pneumoconiosis (Ndlovu et al, 2017;Ndlovu et al, 2016;Nelson et al, 2010;Naidoo et al, 2005;Corbett et al, 1999;Hnizdo et al, 1993;Nelson et al, 2011;Murray et al, 1996). The presence of slate-grey to dense black silica dust-laden macrophages (sometimes visible silicate crystals), asbestos fibres and asbestos bodies and pigment-laden macrophages, and anthracitic pigmentation (coal dust) are evidence for exposure, but they are not sufficient for the diagnosis of pneumoconiosis (Landrigan, 2016). On the other hand, the absence of these lesions does not exclude a diagnosis of pneumoconiosis (Landrigan, 2016).…”

Section: How the Risk Factor May Impact The Outcomementioning

confidence: 99%

“…The presence of slate-grey to dense black silica dust-laden macrophages (sometimes visible silicate crystals), asbestos fibres and asbestos bodies and pigment-laden macrophages, and anthracitic pigmentation (coal dust) are evidence for exposure, but they are not sufficient for the diagnosis of pneumoconiosis (Landrigan, 2016). On the other hand, the absence of these lesions does not exclude a diagnosis of pneumoconiosis (Landrigan, 2016). Studies in rodent disease models confirm a role of crystalline silica and asbestos fibres in the etiology of silicosis and asbestosis, respectively.…”

Section: How the Risk Factor May Impact The Outcomementioning

confidence: 99%

See 1 more Smart Citation

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis

Mandrioli

Schlünssen

Ádám

et al. 2018

Environment International

View full text Add to dashboard Cite

show abstract

Section: How the Risk Factor May Impact The Outcomementioning

confidence: 99%

Section: How the Risk Factor May Impact The Outcomementioning

confidence: 99%

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis

Mandrioli

Schlünssen

Ádám

et al. 2018

Environment International

View full text Add to dashboard Cite

show abstract

“…Landrigan and colleagues [2] and the Collegium Ramazzini [2] had previously criticized the Helsinki Criteria [2,3]. The Helsinki Criteria committee responded that its report did "not make recommendations about methods for asbestos fiber analysis [4]".…”

Section: Introductionmentioning

confidence: 99%

A Critique of Helsinki Criteria for Using Lung Fiber Levels to Determine Causation in Mesothelioma Cases

Tran¹,

Egilman

Rigler³

et al. 2021

Annals of Global Health

View full text Add to dashboard Cite

Asbestos is a known human carcinogen and the chief known cause of mesothelioma. In 1997, a group of experts developed the Helsinki Criteria, which established criteria for attribution of mesothelioma to asbestos. The criteria include two methods for causation attribution: 1) a history of significant occupational, domestic, or environmental exposure and/or 2) pathologic evidence of exposure to asbestos. In 2014, the Helsinki Criteria were updated, and these attribution criteria were not changed. However, since the Helsinki Criteria were first released in 1997, some pathologists, cell biologists, and others have claimed that a history of exposure cannot establish causation unless the lung asbestos fiber burden exceeds "the background range for the laboratory in question to attribute mesothelioma cases to exposure to asbestos." This practice ignores the impact on fiber burden of clearance/translocation over time, which in part is why the Helsinki Criteria concluded that a history of exposure to asbestos was independently sufficient to attribute causation to asbestos.

show abstract

“…The cigarette smoke is the primary risk factor for the development of lung cancer and is estimated to be responsible for approximately 90% of all lung cancers [24], followed by asbestos [28], and radon [27]. More than 300 harmful substances with 40 known potent carcinogens were discovered in tobacco smoke.…”

Section: Lung Cancer-molecular Classification and Survival Ratesmentioning

confidence: 99%

Noncoding RNAs in Lung Cancer Angiogenesis

Berindan‐Neagoe¹,

Braicu²,

Gulei³

et al. 2017

Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy

View full text Add to dashboard Cite

Lung cancer is the major death-related cancer in both men and women, due to late diagnostic and limited treatment efficacy. The angiogenic process that is responsible for the support of tumor progression and metastasis represents one of the main hallmarks of cancer. The role of VEGF signaling in angiogenesis is well-established, and we summarize the role of semaphorins and their related receptors or hypoxia-related factors role as prone of tumor microenvironment in angiogenic mechanisms. Newly, noncoding RNA transcripts (ncRNA) were identified to have vital functions in miscellaneous biological processes, including lung cancer angiogenesis. Therefore, due to their capacity to regulate almost all molecular pathways related with altered key genes, including those involved in angiogenesis and its microenvironment, ncRNAs can serve as diagnosis and prognosis markers or therapeutic targets. We intend to summarize the latest progress in the field of ncRNAs in lung cancer and their relation with hypoxia-related factors and angiogenic genes, with a particular focus on ncRNAs relation to semaphorins.

show abstract

Comments on the 2014 Helsinki Consensus Report on Asbestos

Abstract: The sections of the 2014 Helsinki Consensus Report on asbestos, asbestosis, and cancer dealing with pathologic diagnosis of the diseases caused by asbestos appear to have been influenced by members of the Expert Committee with undisclosed financial conflicts of interest.

Cited by 11 publications

References 21 publications

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis

A Critique of Helsinki Criteria for Using Lung Fiber Levels to Determine Causation in Mesothelioma Cases

Noncoding RNAs in Lung Cancer Angiogenesis

Contact Info

Product

Resources

About