Comments regarding “Hair regrowth during chemotherapy after scalp cooling technique”

Silva, Giselle de Barros; Donati, Aline; Hurk, Corina J. van den

doi:10.1111/ijd.13526

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Scalp cooling induces hair regrowth during chemotherapy even when initiated after hair loss. Some cases have reportedly experienced hair regrowth using scalp cooling even after hair loss during chemotherapy without scalp cooling [10,11]. However, no head cover rates, which are the ratios of the patients without wigs, vary depending on the type of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Hair regrowth using a properly fitted scalp cooling cap during adjuvant chemotherapy for breast cancer

2019

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Patients with breast cancer desire to avoid chemotherapy-induced alopecia because it induces mental stress during treatment. Scalp cooling can suppress chemotherapy-induced alopecia without increasing the risk of scalp metastasis; however, in certain cases, alopecia cannot be prevented. The use of properly fitted scalp cooling caps has not yet been explored in Asian patients. Here, we report a case of hair regrowth using a properly fitted scalp cooling cap during adjuvant chemotherapy for breast cancer. A 51-year-old Japanese woman who was recalled by screening mammography for grouped amorphous calcifications and architectural distortion visited our hospital. Preoperative diagnosis was cT2N0M0 cStage IIA. Sentinel lymph node biopsy revealed axillary metastasis; hence, left mastectomy and axillary lymph node resection were performed. Pathological diagnosis revealed ER/PgR-positive and HER2-negative invasive lobular carcinoma (pT3N2M0 pStage IIIA). Adjuvant chemotherapy comprising four cycles of docetaxel every 3 weeks as well as four cycles of FEC every 3 weeks was performed with scalp cooling. After the first cycle of docetaxel, a 10-cm oval hair loss patch was observed at the vertex of the patient's head. Assuming the scalp cooling cap was not efficiently in contact with the vertex of the patient's head, we modified and properly fit the scalp cooling cap. After the third cycle of docetaxel, hair regrowth at the vertex began and gradually increased during chemotherapy. The patient did not require hair wigs during and after adjuvant chemotherapy. The scalp cooling cap should be carefully fitted at the vertex of the head, which is difficult to be covered, particularly in the case of Japanese patients. In addition, further development of properly fitted scalp cooling caps suitable for various individuals is necessary.

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Section: Discussionmentioning

confidence: 99%

Hair regrowth using a properly fitted scalp cooling cap during adjuvant chemotherapy for breast cancer

2019

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“…164 Scalp cooling has been reported effective in 3 breast cancer patients treated with taxane-based chemotherapy and with CIA grade 2 (CTCAE) in order to prevent alopecia in future chemotherapy sessions, and consequently allow sooner reestablishment of scalp hair density, however, the risk of frostbite should be considered. 165 In general, precooled caps remain very popular because of their widespread availability. Although four cases of thermal injury has been reported due to improper caps applications.…”

Section: Anticancer Therapy-induced Alopeciamentioning

confidence: 99%

Hair disorders in patients with cancer

Freites-Martínez

Shapiro

Goldfarb

et al. 2019

Journal of the American Academy of Dermatology

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Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced alopecia has been well-documented mainly in the oncology literature, however the effect of other alterations such as radiation-induced alopecia, hirsutism, changes in hair color or texture on quality of life have not been described. This article reviews clinically significant therapy-related hair disorders in cancer patients, underlying pathophysiological mechanisms, severity grading scales, patient reported quality of life instruments, management strategies, and future translational research opportunities.

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“…A reduction of more than 50% of CIA by scalp cooling (SC) has been reported in clinical studies. 13 However, most studies have not lived up to requirements of a clinical routine setting, eg SC was mostly applied to single-agent chemotherapy regimens rather than the much more frequently applied combined chemotherapy regimens. Moreover, established evidence has predominantly highlighted SC efficacy in terms of the quantification of effective hair loss.…”

Section: Introductionmentioning

confidence: 99%

PRO Hair Safe Study: The Patient’s Perspective on the Effects of Scalp Cooling on Hair Preservation

Brunner¹,

Egle²,

Ritter³

et al. 2023

BCTT

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Purpose: Alopecia has been reported a distressing side-effect of chemotherapy for breast cancer patients (BCP) that is highly relevant for quality of life during treatment. For the prevention of chemotherapy-induced alopecia, scalp cooling (SC) has been reported to be an effective and safe intervention. However, data on the patient's perspective on effectiveness and applicability of SC in a clinical routine setting are scarce. In this comparative study, we aimed at a longitudinal assessment of patient-reported outcome (PRO) data on the effect of SC on alopecia and its effect on symptoms and functional health when applied in clinical routine in BCP receiving taxane or anthracycline-based chemotherapy. Patients and Methods: Study participants were allocated either to the intervention group receiving SC or to the control group based on patient preference (non-randomized study). All patients completed PRO-measures on hair preservation (EORTC Item Library items on hair loss), symptom and functional health measures (EORTC QLQ-C30 and -BR23) and the Body Image Scale (BIS). Outcomes were assessed at chemotherapy start (baseline), mid-chemotherapy, last chemotherapy cycle, 3 months follow-up and 6-9 months follow-up. Results: Overall, we included 113 patients: 75 patients underwent SC (mean age = 51.3 years, 52.7% premenopausal); 38 patients standard care (mean age = 55.6 years, 39.5% premenopausal). A total of 53 patients (70.7%) discontinued SC, with 39 patients (73.5%) stating alopecia as the primary reason. On average, BCP stayed on treatment with the cooling cap for 40.2% of the duration of their chemotherapy (SD 25.3%). In an intention-to-treat analysis, we found no difference between the SC group and the control group with regard to their patient-reported hair loss (p=0.831) across the observation period, overall QOL (p=0.627), emotional functioning (p=0.737), social functioning (p=0.635) and body image (p=0.463) did not differ between groups. Conclusion:We found a high rate of SC-decliners and no beneficial effects of SC for patient-reported hair loss, symptoms and functional health. The efficacy and tolerability of SC applied in a clinical routine setting hence appeared to be limited. The further determination and up-front definition of criteria prognostic for effectiveness of SC may be helpful to identify patient subgroups that may experience a treatment benefit.

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Comments regarding “Hair regrowth during chemotherapy after scalp cooling technique”

Cited by 5 publications

References 7 publications

Hair regrowth using a properly fitted scalp cooling cap during adjuvant chemotherapy for breast cancer

Hair regrowth using a properly fitted scalp cooling cap during adjuvant chemotherapy for breast cancer

Hair disorders in patients with cancer

PRO Hair Safe Study: The Patient’s Perspective on the Effects of Scalp Cooling on Hair Preservation

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