Mangrove forest ecosystems are critically threatened in West-Central Africa due to minimal management and policy efforts. This is partly caused by insufficient knowledge about the economic and ecological value of mangrove ecosystems, which provide important ecosystem services, such as fish, flood prevention, erosion prevention, water regulation, and timber products. A strategy to improve mangrove ecosystem management would be to improve public understanding of the ecosystem's values. We studied these drivers on a regional scale, using socio-economic and grey literature and consultations with experts, thereby focusing on the period from 1980 to 2006. Wood harvesting, conversion of mangroves for agriculture, and bio-fuel plantations were important drivers of mangrove forest change. Coastal development is the most important direct driver of mangrove forest change, especially between 2000 and 2006, a period that coincides with large oil discoveries in the region. About 60% of all industries within the region are located near the coast, which is expected to attract about 50 million people by 2025. Future policies should target the risks of declining mangrove ecosystems in West-Central Africa. This requires focusing on adaptive strategies, reviewing existing coastal and marine ecosystem policies, and developing an integrated coastal management strategy for the region.