Commercial applications of algae: opportunities and constraints

Radmer, Richard; Parker, Barry

doi:10.1007/bf02186062

Cited by 90 publications

(47 citation statements)

References 13 publications

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“…is their ability to support high biomass productivity under both autotrophic and heterotrophic culture modes (Gladue and Maxey, 1994;Radmer and Parker, 1994;Lee, 1997;Doucha and Livansky, 2012). Under photoautotrophic conditions, most Chlorella spp.…”

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confidence: 99%

Genomic Foundation of Starch-to-Lipid Switch in Oleaginous Chlorella spp.

et al. 2015

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The ability to rapidly switch the intracellular energy storage form from starch to lipids is an advantageous trait for microalgae feedstock. To probe this mechanism, we sequenced the 56.8-Mbp genome of Chlorella pyrenoidosa FACHB-9, an industrial production strain for protein, starch, and lipids. The genome exhibits positive selection and gene family expansion in lipid and carbohydrate metabolism and genes related to cell cycle and stress response. Moreover, 10 lipid metabolism genes might be originated from bacteria via horizontal gene transfer. Transcriptomic dynamics tracked via messenger RNA sequencing over six time points during metabolic switch from starch-rich heterotrophy to lipid-rich photoautotrophy revealed that under heterotrophy, genes most strongly expressed were from the tricarboxylic acid cycle, respiratory chain, oxidative phosphorylation, gluconeogenesis, glyoxylate cycle, and amino acid metabolisms, whereas those most down-regulated were from fatty acid and oxidative pentose phosphate metabolism. The shift from heterotrophy into photoautotrophy highlights up-regulation of genes from carbon fixation, photosynthesis, fatty acid biosynthesis, the oxidative pentose phosphate pathway, and starch catabolism, which resulted in a marked redirection of metabolism, where the primary carbon source of glycine is no longer supplied to cell building blocks by the tricarboxylic acid cycle and gluconeogenesis, whereas carbon skeletons from photosynthesis and starch degradation may be directly channeled into fatty acid and protein biosynthesis. By establishing the first genetic transformation in industrial oleaginous C. pyrenoidosa, we further showed that overexpression of an NAD(H) kinase from Arabidopsis (Arabidopsis thaliana) increased cellular lipid content by 110.4%, yet without reducing growth rate. These findings provide a foundation for exploiting the metabolic switch in microalgae for improved photosynthetic production of food and fuels.

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confidence: 99%

Genomic Foundation of Starch-to-Lipid Switch in Oleaginous Chlorella spp.

et al. 2015

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“…Учир нь бичил замгийг дээд ургамалтай харьцуулахад богино хугацаанд их хэмжээний бүтээгдэхүүн үйлдвэрлэх чадвартай, фотосинтезийн эрчимжилт болон тэжээллэг чанараараа илүү өндөр байдаг. Тухайлбал: Chlorella, Dunaliella, Spirulina зэрэг төрлийг бичил замгийн судлаачид ихээхэн сонирхох болсон ба эдгээр замгийг ашиглан хүнс тэжээлийн нэмэлт, хүнс ба гоо сайхны бүтээгдэхүүн, глицерин, биотүлш зэрэг эрүүл мэнд, экологийн өндөр ашигтай бүтээгдэхүүнийг ихээр үйлдвэрлэх болсон [2,3,4].…”

Section: оршилunclassified

Dunaliella Замгийн Физиологи, Биохимийн Судалгааны Дүн

Odgerel¹,

Цэрэндулам²

2016

Proc. Mong. Acad. Sci.

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Дэлхийн олон оронд бичил замгийн олон төрөл зүйлийг янз бүрийн зорилгоор ашиглаж байна. Учир нь бичил замгийг дээд ургамалтай харьцуулахад богино хугацаанд их хэмжээний бүтээгдэхүүн үйлдвэрлэх чадвартай, фотосинтезийн эрчимжилт болон тэжээллэг чанараараа илүү өндөр байдаг. Тухайлбал: Chlorella, Dunaliella, Spirulina зэрэг төрлийг бичил замгийн судлаачид ихээхэн сонирхох болсон ба эдгээр замгийг ашиглан хүнс тэжээлийн

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“…Fermentative growth of naturally heterotrophic microalgae has resulted in dry biomass accumulation to 100 g/Uter (3,27), which is 10 to 50 times the yields obtained by using light-dependent culture systems. Fermentation-based systems can reduce production costs of microalgae by an order of magnitude relative to that incurred by photosynthesisbased production; cost reduction analyses factor in expenses for both fixed-carbon supplementation and equipment operation (28). Commercial benefits of fermentation-based systems result from increased biomass, productivity, harvesting efficiency, and reduced losses from contamination.…”

Section: Reportsmentioning

confidence: 99%

Telomere Length and Genomic Stability as Indicators of Breast Cancer Risk

Baur¹

2003

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Commercial applications of algae: opportunities and constraints

Cited by 90 publications

References 13 publications

Genomic Foundation of Starch-to-Lipid Switch in Oleaginous Chlorella spp.

Genomic Foundation of Starch-to-Lipid Switch in Oleaginous Chlorella spp.

Dunaliella Замгийн Физиологи, Биохимийн Судалгааны Дүн

Telomere Length and Genomic Stability as Indicators of Breast Cancer Risk

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