Commercial hydrogels for biomedical applications

Abstract

Hydrogels are polymeric networks having the ability to absorb a large volume of water. Flexibility, versatility, stimuli-responsive, soft structure are the advantages of hydrogels. It is classified based on its source, preparation, ionic charge, response, crosslinking and physical properties. Hydrogels are used in various fields like agriculture, food industry, biosensor, biomedical, etc. Even though hydrogels are used in various industries, more researches are going in the field of biomedical applications because of its resembles to living tissue, biocompatibility, and biodegradability. Here, we are mainly focused on the commercially available hydrogels used for biomedical applications like wound dressings, contact lenses, cosmetic applications, tissue engineering, and drug delivery.

Relationships between the material properties of silicone hydrogels: Desiccation, wettability and lubricity

“…52,53 Many other factors can contribute to the modification of SiHy surface and to its tribological performance in vivo: lipid and protein deposits, inter-and intraindividual variability, the state of the corneal and conjuctival epithelium etc. [1][2][3][4] These factors can also mutually interfere with each other and alleviate or synergistically facilitate their effects. Therefore in order to see whether the factors that determine the CoF of SiHy and also the actual correlation between the in vitro properties and the clinical performance of the materials, the in vitro results should be collated with the CoF values of the worn contact lenses and with the corresponding data on the PLTF stability and the patient comfort.…”

“…2 Other implementations of SiHy include weekly disposable CL, drug delivery vehicles and tissue engineering implants. 3 In order to ensure the visual acuity and the comfort of wear of the contact lens in vivo at the ocular surface, SiHy should be well optimized to maintain the stability of the 2-3 mm thin pre-lens tear film (PLTF) and to ensure the lubrication, i.e. the low coefficient of friction, between the eyelid wiper and the CL surface at blink.…”

Multifunctional Biopolymers‐Based Composite Materials for Biomedical Applications: A Systematic Review

“…On the other hand, naturally occurring biopolymers based hydrogels mimic different extracellular matrix features of the and posses the capability to straight migration, organization and growth of cells [31,32] . Biopolymers of polypeptide and polysaccharide are well‐known and widely studied for the formation of hydrogel [33,34] . These materials exhibit all the physiochemical properties that assure the development of hydrogels for biomedical applications [35,36] .…”

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

“…Commercially available hydrogels for tissue engineering are scaffolds, such as Mebiol ® gel and Corning ® PuraMatrix™ peptide hydrogel, which are designed for cell growth and differentiation, and are used as external in vitro devices. Besides cell scaffolding, hydrogels are also employed in external wound dressing, and are composed of highly hydrophilic synthetic polymers frequently in combination with polysaccharides such as cellulose, alginates and hyaluronic acid [ 14 ]. Although their use in wound dressing is quite popular in regenerative medicine, the high production costs for more specific and finely designed hydrogels hinders their large-scale use in internal tissue engineering and drug delivery; thus, they have not found their way into the market yet [ 9 ].…”