One of the most critical challenges that large companies, small enterprises and research institutes face, when commercializing their innovations, is the transfer process at the moment of scaling up. These organizations often transfer their innovation to either existing business units or create a new business entirely. The process of transferring innovations to an existing unit is known as corporate venture, while creating a new business is called spinoff. Both processes have been studied separately, but not yet together and from different business sectors and countries. In order to understand both processes, this article compares the commercialization of disruptive innovations from these sectors: electronics, information technology, telecommunications, engineering, healthcare, biotechnology or research equipment. The article used multiple case study methodology from commercialization projects carried out in large, small and medium-sized companies and research institutes based in Spain, Germany, UK and Finland. The findings showed that certain activities needed to be done at pre-transition /commercialization, transition/commercialization, and post-transition/commercialization phases to reach a successful transition. Furthermore, the study provides similarities between the corporate venture and spinoff approaches that include team formation, network development and getting the commitment from the company and stakeholders. Additionally, the article outlines divergences between the approaches which consist of innovation readiness, knowledge management or the activities of the post-transition phase. The article also provides insight for innovation scholars, commercialization practitioners, and business enterprises. Therefore, the article contributes to the commercialization of disruptive innovations.